Candida antarctica lipase B (CAL-B)-catalyzed carbon-sulfur bond addition and controllable selectivity in organic media
Candida antarctica lipase B (CAL-B)-catalyzed carbon-sulfur bond addition and controllable selectivity in organic media
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南极假丝酵母脂肪酶 B (CAL-B) 催化有机介质中的碳硫键加成和可控选择性
DOI：
10.1002/adsc.200800207
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发表时间：
2008-09-01
影响因子：
5.4
通讯作者：
Lin, Xian-Fu
中科院分区：
文献类型：
--
作者：
Lou, Feng-Wen;Liu, Bo-Kai;Lin, Xian-Fu
描述了一种新的酶促混合方案，用于南极念珠菌脂肪酶B （CAL-B）催化碳硫键加成。设计了一些对照实验来证明CAL-B的催化特异性。在不同的有机介质中，反马尔可夫尼科夫加成和马尔可夫加成具有选择性。在50℃的CAL-B催化下合成了一系列含硫醚的酯官能团，并用红外、核磁共振、ESI-MS等光谱方法对产物进行了表征。
A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL-B)-catalyzed carbon-sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL-B. Selectivity between anti-Markovnikov addition and Markovnikov addition was achieved in different organic media. A series of thioether-containing ester functional groups was synthesized under the catalysis of CAL-B at 50 degrees C. All the products were characterized by spectroscopic methods (IR, NMR, ESI-MS).