DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY
DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY
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西方电学研究中膳食维生素 A 与癌症风险
DOI：
10.1016/s0140-6736(81)91435-5
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
J. Stamler
中科院分区：
文献类型：
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作者：
R. Shekelle;Shuguey Liu;W. Raynor;M. Lepper;C. Maliza;A. Rossof;O. Paul;A. Shryock;J. Stamler
在一项对1954名中年男性进行的前瞻性流行病学研究中，膳食维生素原A（胡萝卜素）摄入量与19年肺癌发病率呈负相关。在胡萝卜素摄入量分布的第一（最低）到第四四个四分位数中，肺癌的相对风险分别为7.0、5.5、3.0和1.0，吸烟30年或更长时间的男性分别为8.1、5.6、3.9和1.0。摄入预制维生素A（视黄醇）和其他营养素的摄入量与肺癌的风险没有显着相关。胡萝卜素和视黄醇的摄入量与其他癌症的风险没有显着相关性，尽管对于随后发展为头颈部表皮样癌的男性，胡萝卜素的摄入量往往低于平均水平。这些结果支持了饮食β-胡萝卜素降低肺癌风险的假设。然而，吸烟也会增加患肺癌以外其他严重疾病的风险，而且没有证据表明饮食中的类胡萝卜素会以任何方式影响这些其他风险。
Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.