Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial
Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial
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DOI：
10.1097/mao.0000000000002207
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发表时间：
2019-06-01
影响因子：
2.1
通讯作者：
Barker, Anthony
中科院分区：
文献类型：
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作者：
Godbehere, Joanna;Sandhu, Jaswinder;Barker, Anthony
目的：为了确定θ脉冲重复经颅磁刺激是否是一种有效的治疗慢性耳鸣相比，对照刺激。研究设计：一个双臂，单盲，随机对照试验比较积极的治疗组安慰剂对照组。设置：神经耳科第三级转诊中心。患者：40名新的和现有的慢性单侧或双侧耳鸣患者从专业听力和平衡诊所招募。干预措施：受试者被随机分为两组，分别代表治疗亚类和假亚类。使用超快速刺激器（2.2.特斯拉、Magstim Inc.、Wales，UK）使用圆形递送线圈。治疗提供了连续5 days.Main Outcome Measure：Tintin功能指数（TFI）评分记录治疗前，治疗后立即，2周，4周后治疗和compared.Results：TFI评分进行了分析，使用Shapiro-Wilk检验，发现呈正态分布。然后进行配对Student t检验。积极治疗组和对照组有一个显着的改善，他们的TFI评分治疗后，然而，积极治疗和假治疗groups.Conclusion之间没有显着差异：这项研究表明，一个显着的安慰剂效应与假治疗后，可能表明，重复经颅磁刺激没有治疗慢性耳鸣的治疗用途。
Objective: To determine whether theta burst repetitive transcranial magnetic stimulation is an effective treatment for chronic tinnitus compared with a control stimulus.Study Design: A two-arm, single-blind, randomized controlled trial comparing an active treatment group to a placebo control group.Setting: Neurotology department of a tertiary referral center.Patients: Forty new and existing patients with chronic unilateral or bilateral tinnitus were recruited from specialist hearing and balance clinics. Interventions: The subjects were randomized into two groups representing the treatment and sham subcategories. Two 40 second trains, 15 minutes apart of transcranial stimulation was provided using a super rapid stimulator (2.2. Tesla,Magstim Inc., Wales, UK) using a circular delivery coil. Treatment was provided over 5 consecutive days.Main Outcome Measure: Tinnitus functional index (TFI) scores were recorded before treatment, immediately after treatment, 2 weeks, and at 4 weeks following treatment and compared.Results: TFI scores were analyzed using the Shapiro-Wilk test and found to be normally distributed. A paired Student t test was then performed. Both the active treatment group and control group had a significant improvement in their TFI scores following treatment; however, there was no significant difference between active treatment and sham treatment groups.Conclusion: This study demonstrated a significant placebo effect following treatment with sham therapy and may suggest that repetitive transcranial magnetic stimulation does not have a therapeutic use in treating chronic tinnitus.