HLA ANTIGENS AND ACETYLCHOLINE-RECEPTOR ANTIBODIES IN PENICILLAMINE INDUCED MYASTHENIA-GRAVIS
HLA ANTIGENS AND ACETYLCHOLINE-RECEPTOR ANTIBODIES IN PENICILLAMINE INDUCED MYASTHENIA-GRAVIS
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DOI：
10.1136/bmj.286.6362.338
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发表时间：
1983-01-01
影响因子：
105.7
通讯作者：
CHRISTIANSEN, FT
中科院分区：
文献类型：
--
作者：
GARLEPP, MJ;DAWKINS, RL;CHRISTIANSEN, FT
在与青霉胺治疗[类风湿性关节炎]相关的重症肌无力患者中研究了乙酰胆碱受体和 HLA 抗原的抗体。这些患者的抗乙酰胆碱受体的特性与特发性重症肌无力患者的特性在特异性和亲和力方面有所不同。与对照组相比，这些患者的 HLA Bw35 和 DR1 患病率较高，而与特发性重症肌无力患者相比，B8 和 DR3 的患病率较低。与类风湿性关节炎患者相比，他们的 DR4 频率降低。支持青霉胺在遗传易感个体中诱导重症肌无力的作用。
Antibodies to the acetylcholine receptor and HLA antigens were studied in patients with myasthenia gravis occurring in association with penicillamine treatment [of rheumatoid arthritis]. The properties of the antiacetylcholine receptor in these patients differed from those in patients with idiopathic myasthenia gravis in terms of specificity and affinity. These patients had an increased prevalence of HLA Bw35 and DR1 compared to controls and a decreased frequency of B8 and DR3 compared to patients with idiopathic myasthenia gravis. They had a decreased frequency of DR4 compared to patients with rheumatoid arthritis. A role of penicillamine in the induction of myasthenia gravis in genetically predisposed individuals is supported.