Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography
Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography
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DOI：
10.1117/1.jbo.21.6.066008
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发表时间：
2016-06-01
影响因子：
3.5
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Chu, Zhongdi;Lin, Jason;Wang, Ruikang K.
光学相干断层扫描血管造影（OCTA）在临床上可用于黄斑微血管系统的定性评估。然而，需要全面的定量工具来帮助客观分析 OCT 血管造影。很少有研究报道使用单一定量指数来描述 OCT 血管造影中的血管密度。在本研究中，我们引入了OCT血管造影的五指标定量分析，试图从多个角度检测和评估血管异常。这些指数包括血管面积密度、血管骨架密度、血管直径指数、血管周长指数和血管复杂性指数。我们通过五个说明性案例展示了所提议指数的实用性。对健康病例和病情稳定的病例进行了重复性测试，组间系数小于 0.031。结果表明，我们提出的定量分析可作为传统 OCTA 的补充，用于疾病诊断和治疗监测。 (C) 作者。由 SPIE 根据 Creative Commons Attribution 3.0 Unported 许可证发布。
Optical coherence tomography angiography (OCTA) is clinically useful for the qualitative assessment of the macular microvasculature. However, there is a need for comprehensive quantitative tools to help objectively analyze the OCT angiograms. Few studies have reported the use of a single quantitative index to describe vessel density in OCT angiograms. In this study, we introduce a five-index quantitative analysis of OCT angiograms in an attempt to detect and assess vascular abnormalities from multiple perspectives. The indices include vessel area density, vessel skeleton density, vessel diameter index, vessel perimeter index, and vessel complexity index. We show the usefulness of the proposed indices with five illustrative cases. Repeatability is tested on both a healthy case and a stable diseased case, giving interclass coefficients smaller than 0.031. The results demonstrate that our proposed quantitative analysis may be useful as a complement to conventional OCTA for the diagnosis of disease and monitoring of treatment. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.