A new, objective, quantitative scale for measuring local skin responses following topical actinic keratosis therapy with ingenol mebutate.
A new, objective, quantitative scale for measuring local skin responses following topical actinic keratosis therapy with ingenol mebutate.
复制标题
一种新的，客观的定量量表，用于测量局部肌动症性角化作用治疗的局部皮肤反应。
DOI：
10.1007/s13555-014-0059-9
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发表时间：
2014-12
影响因子：
3.4
通讯作者：
Katsamas, Janelle
中科院分区：
文献类型：
--
作者：
Rosen, Robert;Marmur, Ellen;Anderson, Lawrence;Welburn, Peter;Katsamas, Janelle
Local skin responses (LSRs) are the most common adverse effects of topical actinic keratosis (AK) therapy. There is currently no method available that allows objective characterization of LSRs. Here, the authors describe a new scale developed to quantitatively and objectively assess the six most common LSRs resulting from topical AK therapy with ingenol mebutate. The LSR grading scale was developed using a 0–4 numerical rating, with clinical descriptors and representative photographic images for each rating. Good inter-observer grading concordance was demonstrated in peer review during development of the tool. Data on the use of the scale are described from four phase III double-blind studies of ingenol mebutate (n = 1,005). LSRs peaked on days 4 (face/scalp) or 8 (trunk/extremities), with mean maximum composite LSR scores of 9.1 and 6.8, respectively, and a rapid return toward baseline by day 15 in most cases. Mean composite LSR score at day 57 was generally lower than at baseline. The LSR grading scale is an objective tool allowing practicing dermatologists to characterize and compare LSRs to existing and, potentially, future AK therapies. The online version of this article (doi:10.1007/s13555-014-0059-9) contains supplementary material, which is available to authorized users.
