Nebularic acids and nebularilactones, novel drimane sesquiterpenoids from the fungus Lepista nebularis
Nebularic acids and nebularilactones, novel drimane sesquiterpenoids from the fungus Lepista nebularis
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DOI：
10.1002/e.joc.200500869
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发表时间：
2006-03-27
影响因子：
2.8
通讯作者：
Hertweck, C
中科院分区：
文献类型：
--
作者：
Wangun, HVK;Dörfelt, H;Hertweck, C
采用生物活性导向色谱法从云香蘑（Lepista nebularis）中分离得到4个去甲补身烷型倍半萜类化合物，分别为云香蘑酸A（1）和B（2）以及云香蘑内酯A（3）和B（4），并通过质谱和核磁共振波谱进行了结构鉴定。以α，β-环氧羧酸酯部分为特征的水松酸A（1），特别是水松酸B（2），显示出抗真菌和抗细菌活性。(c)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2006.
Four (nor-)drimane sesquiterpenoids, nebularic acids A (1) and B (2) and nebularilactones A (3) and B (4), were isolated from a cultured Lepista nebularis strain by bioassay-guided chromatography, and their structures were elucidated by mass spectrometry and NMR spectroscopy. Nebularic acid A (1) and in particular nebularic acid B (2), which features an alpha,beta-epoxy carboxylate moiety, show antifungal and antibacterial activities. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.