Effect of changing dietary fat saturation on low-density lipoprotein metabolism in man.
Effect of changing dietary fat saturation on low-density lipoprotein metabolism in man.
复制标题
改变膳食脂肪饱和度对人类低密度脂蛋白代谢的影响。
DOI：
10.1152/ajpendo.1981.241.1.e57
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Brown,WV
中科院分区：
文献类型：
--
作者：
Turner,JD;Le,NA;Brown,WV
研究了不同脂肪饱和度的膳食引起低密度脂蛋白（LDL）水平变化的机制。周转125 I-LDL测定8例II型高脂蛋白血症和7例正常对照组在两个饮食期内含有40%的热量，无论是红花油（多不饱和脂肪，PSF）或猪油（饱和脂肪，SF）。在饱和脂肪组中，两组均观察到LDL载脂蛋白和LDL胆固醇水平较高。低密度脂蛋白水平升高的受试者（II型）表现出更显着的多不饱和脂肪的影响，低密度脂蛋白产生率降低25%，而对照组仅降低10%。在PSF饮食中，II型（12.7 mg.kg-1.day-1）的生产率与正常受试者（10.5 mg.kg-1.day-1）无统计学差异。在这种饮食中，II型受试者的LDL胆固醇水平较高（与对照组相比）是由于分数清除率较低，平均为0.27/天，而正常受试者的平均值为0.39/天。尽管II型高脂蛋白血症患者可能存在原发性清除缺陷，但多不饱和脂肪含量高的饮食可使血浆胆固醇浓度显著降低，这可归因于LDL的产生显著降低。
The mechanism of change in low-density lipoprotein (LDL) levels by diets differing in fat saturation have been studied. Turnover of 125I-LDL was measured in eight subjects with type II hyperlipoproteinemia and in seven normal control subjects during two dietary periods containing 40% of calories as either safflower oil (polyunsaturated fat, PSF) or as lard (saturated fat, SF). Higher levels of LDL apoprotein and LDL-cholesterol were observed in both groups on saturated fat. Subjects with elevated LDL levels (type II) showed a more marked effect of polyunsaturated fat with 25% lower LDL production rate as compared to a reduction of only 10% for the control group. On the PSF diet, the production rate in type II (12.7 mg.kg-1.day-1) was not statistically different from normal subjects (10.5 mg.kg-1.day-1). On this diet, the higher levels of LDL cholesterol in the type II subjects (as compared to controls) were due to a lower fractional clearance rate, mean of 0.27/day compared to a mean of 0.39/day for the normal subjects. Although individuals with type II hyperlipoproteinemia may have a primary clearance defect, the major reduction in plasma cholesterol concentrations achieved with a diet high in polyunsaturated fat can be attributed to a significantly lower LDL production.