Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium.
Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium.
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DOI：
10.1002/eji.201545739
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发表时间：
2015-10
影响因子：
5.4
通讯作者：
Tamburini BA
中科院分区：
文献类型：
--
作者：
Kedl RM;Tamburini BA
次级淋巴基质的功能远远超过对淋巴组织的简单结构支持，在炎症和体内平衡期间提供大量可溶性和膜结合的线索以运输白细胞。最近已经清楚的是，基质细胞可以操纵T细胞应答，通过直接抗原介导的T细胞刺激或更间接地通过病毒感染或疫苗接种后抗原的保留和管理。根据最近的数据，这篇评论提供了一个概述的基质细胞亚群和功能的进展过程中的适应性免疫反应，特别强调抗原捕获和保留的滤泡树突状细胞（FDC），以及最近描述的“抗原存档”功能的淋巴管内皮细胞（LEC）。鉴于其对保护性免疫记忆的维持的影响，我们最后讨论了有关LEC抗原捕获，存档和造血来源的抗原呈递细胞交换的最紧迫的问题。
Secondary lymphoid stroma performs far more functions than simple structural support for lymphoid tissues, providing a host of soluble and membrane-bound cues to trafficking leukocytes during inflammation and homeostasis. More recently it has become clear that stromal cells can manipulate T cell responses, either through direct antigen-mediated stimulation of T cells or more indirectly through the retention and management of antigen after viral infection or vaccination. In light of recent data, this review provides an overview of stromal cell subsets and functions during the progression of an adaptive immune response with particular emphasis on antigen capture and retention by follicular dendritic cells (FDC) as well as the recently described “antigen archiving” function of lymphatic endothelial cells (LEC). Given its impact on the maintenance of protective immune memory, we conclude by discussing the most pressing questions pertaining to LEC antigen capture, archiving and exchange with hematopoetically derived antigen-presenting cells.