Maternal and fetal oxidative stress and intrapartum term fever
Maternal and fetal oxidative stress and intrapartum term fever
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DOI：
10.1016/j.ajog.2010.01.034
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发表时间：
2010-04-01
影响因子：
9.8
通讯作者：
Townsend, Danyelle M.
中科院分区：
文献类型：
--
作者：
Goetzl, Laura;Manevich, Yefim;Townsend, Danyelle M.
目的：产妇绒毛膜炎和胎儿氧化stress.Study设计之间的关联尚未建立：一个巢式病例对照研究进行了一个前瞻性队列内的长期未经产妇：20例（产时发热>100.4华氏度）和20个无发热对照。使用ThioGlo-1（TG-1; Calbiochem，San Diego，CA）荧光巯基检测评估氧化应激。结果：在分娩早期，那些随后出现产时发热的妇女的母体氧化应激（较低的蛋白质巯基）明显较高（79.87 +/- 22.88 vs 127.73 +/- 43.79计数/秒每微克蛋白质; P <0.001）。相比之下，脐带血清巯基在两组之间没有差异（75.77 +/- 14.00 vs 75.04 +/- 17.83计数/秒/μ g蛋白; P = 0.99）结论：我们的数据表明，足月人类胎儿受到保护，免受与产时发热相关的母体氧化应激。然而，母亲在早期劳动的氧化状态与随后的产时发热。最佳的胎儿神经保护需要更精确的致病机制的知识。
OBJECTIVE: The association between maternal chorioamnionitis and fetal oxidative stress has not been well established.STUDY DESIGN: A nested case control study was performed within a prospective cohort of term nulliparous women: 20 cases (intrapartum fever of >100.4 degrees F) and 20 afebrile controls. Oxidative stress was assessed using ThioGlo-1 (TG-1; Calbiochem, San Diego, CA) fluorescent sulfhydryl detection. Median levels (+/- interquartile range) of proteinthiol sulfhydryls were compared.RESULTS: In early labor, maternal oxidative stress (lower protein sulfhydryls) was significantly higher in those women who subsequently had intrapartum fever develop (79.87 +/- 22.88 vs 127.73 +/- 43.79 counts/second per mu g protein; P < .001). In contrast, cord serum sulfhydryls were not different between groups (75.77 +/- 14.00 vs 75.04 +/- 17.83 counts/second per mu g protein; P = .99)CONCLUSION: Our data suggest that the term human fetus is protected from maternal oxidative stress associated with intrapartum fever. However, maternal oxidative status in early labor is associated with subsequent intrapartum fever. Optimal fetal neuroprotection will require a more precise knowledge of pathogenic mechanisms.