BIOCHEMICAL RATIONALE AND MYOCARDIAL TISSUE DATA ON THE EFFECTIVE THERAPY OF CARDIOMYOPATHY WITH COENZYME-Q10
BIOCHEMICAL RATIONALE AND MYOCARDIAL TISSUE DATA ON THE EFFECTIVE THERAPY OF CARDIOMYOPATHY WITH COENZYME-Q10
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DOI：
10.1073/pnas.82.3.901
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
MORTENSEN, SA
中科院分区：
文献类型：
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作者：
FOLKERS, K;VADHANAVIKIT, S;MORTENSEN, SA
采用提取、纯化和高效液相色谱法测定43例心肌病患者心内膜活检标本和血液中辅酶Q10 （CoQ10）的组织水平。活检样本来自常规心导管穿刺后的患者。ⅰ类6例，ⅱ类18例，ⅲ类11例，ⅳ类8例（按照纽约[美国]心脏协会指南分类）。由于伦理原因，无法获得健康心脏的真正对照活组织检查，但按疾病严重程度划分的4类数据可能有理由进行比较。ⅳ类患者辅酶q10水平低于ⅰ类患者（P < 0.01），ⅲ、ⅳ类患者低于ⅰ、ⅱ类患者（P < 0.001）。5例患者在接受辅酶q10治疗2-8个月后获得活检样本。辅酶q10水平升高幅度为20-85%；平均值高于治疗前（P < 0.02）。血液缺陷也随着疾病的严重程度而增加，但不像活检那样明显。这些数据显示心肌缺乏辅酶q10，随着疾病严重程度的增加而增加，并通过治疗减少。这种生物化学与辅酶q10对心肌病的有效治疗有关。
The tissue levels of coenzyme Q10 (CoQ10) in endomyocardial biopsy samples and blood from 43 patients with cardiomyopathy were determined by steps of extraction, purification, and HPLC [high performance liquid chromatography]. The biopsy samples were obtained from the patients after a routine heart catheterization. Six patients were of class I, 18 of class II, 11 of class III and 8 of class IV (classified according to guidelines of the New York [USA] Heart Association). True control biopsies of healthy hearts are not available for ethical reasons, but the data of the 4 classes by severity of disease may be justifiably compared. Patients of class IV had lower (P < 0.01) levels of CoQ10 than those of class I. Patients of classes III and IV had a lower (P < 0.001) level than those of classes I and II. Biopsy samples were obtained from 5 patients after treatment with CoQ10 for 2-8 mo. The increases of CoQ10 levels ranged from 20-85%; the mean value was higher (P < 0.02) than before treatment. Blood deficiencies also increase with severity of disease, but not as markedly as for the biopsies. These data reveal a myocardial deficiency of CoQ10, which is higher with increasing severity of disease and is reduced by therapy. This biochemistry correlates with the effective treatment of cardiomyopathy with CoQ10.