EFFECTS OF ENGORGEMENT WITH MILK AND OF SUCKLING ON MAMMARY BLOOD-FLOW IN RAT
EFFECTS OF ENGORGEMENT WITH MILK AND OF SUCKLING ON MAMMARY BLOOD-FLOW IN RAT
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DOI：
10.1113/jphysiol.1973.sp010300
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发表时间：
1973-01-01
影响因子：
5.5
通讯作者：
LINZELL, JL
中科院分区：
文献类型：
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作者：
HANWELL, A;LINZELL, JL
1.通过测量心输出量和乳腺接收的心输出量的比例来估算大鼠的乳腺血流量。2．当哺乳期第 10 天取出幼仔时，乳腺开始充满乳汁，乳腺血流量从 78 毫升/分钟下降。 100 克组织至 45 毫升/分钟。 8 小时内增加 100 克，并进一步降低至 34 毫升/分钟。 8 小时内增加 100 克，并进一步降低至 34 毫升/分钟。接下来的 16 小时内 100 克。这些变化与心输出量下降和乳腺消耗的心输出量比例下降有关。3．当允许幼仔继续哺乳，但通过用粘合剂密封乳头导管来防止乳汁排出时，8小时内乳腺中收集了更多的乳汁，并且乳腺血流量没有变化（74毫升/分钟。100克）。4。在与幼鼠分开24小时的老鼠中，通过让幼鼠再次吸吮，将乳汁从充血的腺体中排出。乳房血流量在吸奶后并不会立即上升，而是在哺乳 4 小时后才上升，并且在很大程度上与心输出量的增加有关。5．恢复哺乳后，排空腺体和密封乳头的完整腺体中的乳房血流是相同的。6。当从15天的哺乳大鼠中取出幼仔时，24小时后乳腺血流量与腺体中的乳汁量直接相关。7．结论是，乳腺中乳汁的积累不会机械地限制血液流经组织，并且在大鼠中，乳腺血流和乳汁分泌强烈依赖于持续施加的吸吮刺激。
1. Mammary blood flow was estimated in rats by measuring the cardiac output and the proportion of it received by the mammary glands.2. When the young were removed on the 10th day of lactation the mammary glands began to fill with milk and mammary blood flow fell from 78 ml./min. 100 g tissue to 45 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g within 8 hr and decreased further to 34 ml./min. 100 g in the next 16 hr. These changes were associated with both a fall in cardiac output and a fall in the proportion of the cardiac output taken by the mammary glands.3. When the young were allowed to continue suckling, but milk removal was prevented by sealing the teat ducts with adhesive, more milk collected in the mammary glands within 8 hr and mammary blood flow was unchanged (74 ml./min. 100 g).4. In rats which had been separated from their young for 24 hr, milk was removed from the engorged glands by allowing the pups to suckle again. Mammary blood flow did not rise immediately following the removal of milk but only after 4 hr of suckling, and was associated largely with an increase in cardiac output.5. Upon resumption of suckling mammary blood flow was the same in emptied glands, and in full glands with the teats sealed.6. When the young were removed from 15–day lactating rats mammary blood flow after 24 hr was directly related to the volume of milk in the glands.7. It is concluded that the accumulation of milk in the mammary gland does not mechanically restrict the flow of blood through the tissue and that, in the rat, mammary blood flow and milk secretion are strongly dependent on a continually applied suckling stimulus.