Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid.
Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid.
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DOI：
10.1186/s41021-016-0071-7
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Shimoi K
中科院分区：
文献类型：
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作者：
Yasuda MT;Sakakibara H;Shimoi K
乳腺癌是最常见的女性癌症之一，也是女性癌症相关死亡的主要原因。乳腺癌的发病因素是多方面的，其中遗传因素受到了广泛的关注。乳腺癌的DNA损伤是由于长期暴露于雌激素，如17β-雌二醇，日常社会/心理应激源，以及环境化学品，如多环芳烃(PAH)和杂环胺(HCA)。雌激素和应激诱导的DNA损伤是乳腺癌发生和发展的重要因素，目前被认为是乳腺癌化学预防的关键。本文就雌激素和应激诱导的DNA损伤与乳腺癌发生发展的关系作一综述。我们还讨论了最近关于使用饮食中的类黄酮类化合物，如槲皮素和异黄酮类进行化学预防的研究。
Breast cancer is one of the most commonly diagnosed female cancers and a leading cause of cancer-related death in women. Multiple factors are responsible for breast cancer and heritable factors have received much attention. DNA damage in breast cancer is induced by prolonged exposure to estrogens, such as 17β-estradiol, daily social/psychological stressors, and environmental chemicals such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs). DNA damage induced by estrogen and stress is an important factor in the pathogenesis and development of breast cancer and is now recognized as a critical provision for chemoprevention of breast cancer. In this review, we summarize the relationships between estrogen- and stress-induced DNA damage with regard to the pathogenesis and development of breast cancer. We also discuss recent investigations into chemoprevention using dietary flavonoids such as quercetin and isoflavones.