Biphasic changes in mesolimbic dopamine signal during cocaine self-administration.
Biphasic changes in mesolimbic dopamine signal during cocaine self-administration.
复制标题
可卡因自我给药期间中脑边缘多巴胺信号的双相变化。
DOI：
10.1097/00001756-199404000-00038
复制
发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Stein,EA
中科院分区：
文献类型：
--
作者：
Kiyatkin,EA;Stein,EA
使用带有 Nafion 涂层碳纤维微电极的高速计时电流分析法来追踪大鼠静脉注射可卡因自我给药 (SA) 行为期间伏核细胞外多巴胺 (DA) 浓度的变化。在可卡因 SA 后立即发现 DA 依赖性电化学信号突然、短暂地减少，而信号在每次按下杠杆之前缓慢增加，在操作响应处达到峰值。普鲁卡因（一种局部麻醉剂）也能维持先前接受 SA 可卡因训练的大鼠的 SA 行为。与可卡因后观察到的情况类似，普鲁卡因 SA 后电化学信号出现剂量依赖性突然下降，尽管预压信号没有增加。这些数据表明，中脑边缘 DA 释放的短期抑制是静脉注射可卡因 SA 的直接后果，并且可能与药物的奖赏作用相关。这种释放抑制似乎与可卡因抑制 DA 再摄取的能力无关，这种机制会导致细胞外 DA 的积累和电化学信号的增加。可卡因对中脑边缘 DA 神经元这两种功能相反的作用的共存可能对于调节可卡因独特的心因性和成瘾特性很重要。
HIGH-SPEED chronoamperometry with Nafion-coated carbon fiber microelectrodes was used to follow changes in extracellular dopamine (DA) concentration in the nucleus accumbens of rats during intravenous cocaine self-administration (SA) behavior. An abrupt, transient decrease in DA-dependent electrochemical signal was found immediately after cocaine SA, whereas the signal slowly increased preceding each lever-press, reaching a peak at the operant response. Procaine, a local anesthetic, also maintained SA behavior in rats previously trained to SA cocaine. Similar to that seen after cocaine, a dose-dependent, abrupt decrease in electrochemical signal was seen following procaine SA, although the pre-pressing signal increase was absent. These data suggest that short-term inhibition of mesolimbic DA release is an immediate consequence of intravenous cocaine SA and may be correlated with the drug's rewarding action. This release inhibition appears to be independent of cocaine's ability to inhibit DA reuptake, a mechanism that would lead to an accumulation of extra-cellular DA and an increase in electrochemical signal. The coexistence of these two functionally opposite actions of cocaine on mesolimbic DA neurons may be important in mediating cocaine's unique psychogenic and addictive properties.
产生产生迁移抑制因子（MIF）的人杂交瘤和分泌针对人MIF的单克隆抗体的鼠杂交瘤。
影响因子：
4.3
作者：
Weiser,WY;Remold,HG;David,JR
通讯作者：
David,JR