Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.
Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.
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右前岛叶和右眼眶额叶皮层之间的静息态功能连接与强迫症的洞察力水平相关
DOI：
10.1016/j.nicl.2017.04.002
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Tan C
中科院分区：
文献类型：
--
作者：
Fan J;Zhong M;Zhu X;Gan J;Liu W;Niu C;Liao H;Zhang H;Yi J;Tan C
尽管突出网络（SN）与精神分裂症的洞察力缺陷有关，但很少有研究探讨强迫症（OCD）洞察力水平的神经生物学基础。本研究旨在探讨强迫症患者的静息状态（rs）功能连通性（FC）是否与洞察力水平相关。我们分析了21名洞察力良好的强迫症患者（OCD- gi）、19名洞察力较差的强迫症患者（OCD- pi）和24名健康对照（hc）的功能性磁共振成像（fMRI）数据。基于种子的全脑FC和ROI（感兴趣区域）连接分析在双侧前岛（AI）和背前扣带皮层（dACC）中进行种子/ROI。研究发现，强迫症- pi组的右侧ai -右侧内侧眶额叶皮质（mOFC）连通性明显下降，且这种异常连通性的价值与强迫症患者的洞察力水平相关。此外，我们发现，相对于HC， OCD-GI组在SN内的右ai -左dACC连通性显著增加（各组总体趋势：OCD-GI > OCD-PI > HC）。我们的研究结果表明，异常的右ai -右mOFC可能介导了强迫症的洞察力缺陷，这可能是由于强迫症相关信念和行为的自我评价信息编码和整合受损。我们的研究结果表明，强迫症- gi和强迫症- pi患者之间存在SN连接分离，并支持将强迫症- gi和强迫症- pi视为两种不同的疾病亚型的观点。我们研究了强迫症- gi和强迫症- pi中SN的功能连通性。OCD-PI患者右侧ai -右侧mOFC连通性下降。强迫症患者的右AI-右mOFC连通性与洞察力水平相关。OCD-GI患者在SN内右ai -左dACC连通性升高。这些结果有助于阐明强迫症的内观呈现。
Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC) of SN was associated with insight level in OCD patients. We analyzed rs-functional magnetic resonance imaging (fMRI) data from 21 OCD patients with good insight (OCD-GI), 19 OCD patients with poor insight (OCD-PI), and 24 healthy controls (HCs). Seed-based whole-brain FC and ROI (region of interest)-wise connectivity analyses were performed with seeds/ROIs in the bilateral anterior insula (AI) and dorsal anterior cingulate cortex (dACC). The right AI-right medial orbital frontal cortex (mOFC) connectivity was found to be uniquely decreased in the OCD-PI group, and the value of this aberrant connectivity correlated with insight level in OCD patients. In addition, we found that the OCD-GI group had significantly increased right AI-left dACC connectivity within the SN, relative to HCs (overall trend for groups: OCD-GI > OCD-PI > HC). Our findings suggest that abnormal right AI-right mOFC FC may mediate insight deficits in OCD, perhaps due to impaired encoding and integration of self-evaluative information about OCD-related beliefs and behaviors. Our findings indicate a SN connectivity dissociation between OCD-GI and OCD-PI patients and support the notion of considering OCD-GI and OCD-PI as two distinct disorder subtypes. We examined the functional connectivity of SN in OCD-GI and OCD-PI. OCD-PI patients had decreased right AI-right mOFC connectivity. Right AI- right mOFC connectivity correlated with insight level in OCD. OCD-GI patients had elevated right AI-left dACC connectivity within SN. These results are helpful toward elucidating insight presentation in OCD.