Release Behavior of Polymeric Vesicles in Solution Controlled by External Electrostatic Field
Release Behavior of Polymeric Vesicles in Solution Controlled by External Electrostatic Field
复制标题
外部静电场控制聚合物囊泡在溶液中的释放行为
DOI：
10.1021/acsmacrolett.6b00699
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发表时间：
2016
影响因子：
5.8
通讯作者：
Jiang Wei
中科院分区：
文献类型：
--
作者：
Wu Ming;Zhu Yutian;Jiang Wei
我们发现两亲嵌段共聚物聚苯乙烯-嵌段聚丙烯酸（PS144-b-PAA22）在二氧六环/水混合物中自组装形成的聚合物囊泡在外加静电场作用下发生变形、破裂并最终分裂成更小的聚合物囊泡。静电场强度越高，囊泡越小。更重要的是，这种由静电场引起的裂变现象可以用来控制囊泡的释放行为。实验结果表明，通过控制静电场强度和释放时间，可以精确地释放包封在囊泡腔内的尼罗红分子。这些发现不仅丰富了外场诱导聚合物结构转变的知识，而且为聚合物体在溶液中的可控释放提供了一种新的、高度便利的方法。
We found that the polymeric vesicles from the self-assembly of amphiphilic block copolymer polystyrene-block-poly(acrylic acid) (PS144-b-PAA22) in the dioxane/water mixture can be deformed, broken and finally divided into smaller ones via the external electrostatic field. The higher the electrostatic field intensity, the smaller the vesicles. More importantly, this fission phenomenon induced by electrostatic field can be used to control the release behavior of the vesicles. Our experimental results show that the Nile Red (NR) molecules encapsulated inside the cavity of vesicles can be accurately released by controlling the electrostatic field intensity and the release time. These findings not only enrich the knowledge for the external field induced transformation of polymer structures, but also provide a new and highly convenient approach for the controllable release of polymersomes in solution.