Congenital tuberculosis: case report and review of the literature
Congenital tuberculosis: case report and review of the literature
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DOI：
10.1080/20469047.2017.1315912
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发表时间：
2018-01-01
影响因子：
1.8
通讯作者：
Chang, Chih-Chen
中科院分区：
文献类型：
--
作者：
Chang, Ching-Wen;Wu, Patricia Wanping;Chang, Chih-Chen
先天性肺结核是罕见的，即使在结核病（TB）流行的地方。一个14天大的女孩出现了3天的发烧和呼吸窘迫的历史。她的母亲在分娩后立即被诊断为播散性结核感染，并通过阳性结核聚合酶链反应（TB-PCR）和随后的腹水和痰培养证实。婴儿一出生就与母亲分开了。她的胸片显示双侧粟粒性结节。根据症状、体征和母亲结核病史，强烈怀疑先天性结核病，并通过TB-PCR和洗胃培养证实。及时给予标准抗结核治疗，结果良好。该病例强调了母亲结核病史和胸部X线片上典型的粟粒型对早期诊断先天性或新生儿结核病的重要性，从而有助于及时治疗和预后。
Congenital tuberculosis is rare, even where tuberculosis (TB) is endemic. A 14-day-old girl presented with a 3-day history of fever and respiratory distress. Her mother was diagnosed with a disseminated TB infection immediately after the delivery which was confirmed by a positive TB-polymerase chain reaction (TB-PCR) and subsequent culture from ascites and sputum. The infant was separated from her mother at birth. Her chest radiograph showed bilateral miliary nodules. Congenital TB was strongly suspected because of the symptoms, signs and maternal TB history, and was confirmed by TB-PCR and culture from the gastric lavage. Timely administration of standard anti-TB therapy resulted in a good outcome. The case highlights the importance of maternal TB history and typical miliary pattern on chest radiography for early diagnosis of congenital or neonatal TB which in turn facilitates prompt treatment and the prognosis.