Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase
Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase
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DOI：
10.1016/j.neures.2005.05.008
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发表时间：
2005-09-01
影响因子：
2.9
通讯作者：
Hori, Y
中科院分区：
文献类型：
--
作者：
Maekawa, M;Watanabe, M;Hori, Y
我们评估了D-氨基酸氧化酶在海马空间学习和长时程增强（LTP）中的作用，因为这种酶代谢D-氨基酸，其中一些增强N-甲基-D-天冬氨酸受体功能。观察了D-氨基酸氧化酶缺失的野生型小鼠和突变型小鼠的Morris水迷宫学习和海马脑片CA 1区的UP。与野生型小鼠相比，突变小鼠在水迷宫中的平台搜索时间显着缩短，海马LTP显着增大。这些结果表明，突变小鼠脑中丰富的D-氨基酸促进海马LTP和空间学习。(c)2005年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
We evaluated the role Of D-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes D-amino-acids, some of which enhance the N-methyl-D-aspartate receptor functions. The Morris water maze learning and the UP in the CAl area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.