Blood donations and risk of coronary heart disease in men.
Blood donations and risk of coronary heart disease in men.
复制标题
男性献血和冠心病风险。
DOI：
10.1161/01.cir.103.1.52
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发表时间：
2001
期刊：
影响因子：
37.8
通讯作者：
Stampfer,MJ
中科院分区：
文献类型：
--
作者：
Ascherio,A;Rimm,EB;Giovannucci,E;Willett,WC;Stampfer,MJ
背景-在实验动物中，铁超载似乎促进动脉粥样硬化和缺血性心肌损伤，但流行病学研究的结果，涉及铁存储冠心病（CHD）的风险一直不一致的方法和结果-我们前瞻性地研究了献血，这有效地减少身体铁存储，在健康专业人员随访研究的参与者之间的CHD的风险。于1992年采用问卷调查法对献血者的一生献血史进行了评估。当时没有诊断出心血管疾病的38244名男性被纳入分析。在4年的随访中，我们记录了328例非致命性心肌梗死和131例冠状动脉死亡。虽然终生献血次数与子样本中较低的血浆铁蛋白水平密切相关，但献血与心肌梗死或致死性CHD的风险无关。与从不献血者相比，献血次数最多的男性（≥30）发生心肌梗死的年龄调整相对危险度（RR）为1.2（95%CI 0.8 - 1.8），在调整了几个冠状动脉危险因素后，该RR没有实质性变化。献血和心肌梗死的风险之间没有显着的关联被发现在分析中仅限于男性与高胆固醇血症或那些谁从来没有使用过抗氧化剂补充剂或aspirin. Conclusions研究结果不支持这一假设，减少体内铁存储降低冠心病的风险。
Background—In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent.Methods and Results—We prospectively studied blood donations, which effectively reduce body iron stores, in relation to the risk of CHD among participants in the Health Professionals Follow-up Study. The lifetime history of blood donation was assessed with a questionnaire in 1992. The 38 244 men who were free of diagnosed cardiovascular disease at that time were included in the analyses. During 4 years of follow-up, we documented 328 nonfatal myocardial infarctions and 131 coronary deaths. Although the number of lifetime blood donations was strongly associated with lower plasma ferritin levels in a subsample, the blood donation was not associated with risk of myocardial infarction or fatal CHD. The age-adjusted relative risk (RR) of myocardial infarction for men in the highest category of blood donations (≥30) compared with never donors was 1.2 (95% CI 0.8 to 1.8), and this RR was not materially changed after adjustment for several coronary risk factors. No significant associations were found between blood donation and the risk of myocardial infarction in analyses restricted to men with hypercholesterolemia or those who never used antioxidant supplements or aspirin.Conclusions—The study results do not support the hypothesis that reduced body iron stores lower CHD risk.