Alcohol intake and colorectal cancer risk: A dose-response meta-analysis of published cohort studies
Alcohol intake and colorectal cancer risk: A dose-response meta-analysis of published cohort studies
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DOI：
10.1002/ijc.22299
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发表时间：
2007-02-01
影响因子：
6.4
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
--
作者：
Moskal, Aurelie;Norat, Teresa;Riboli, Elio
流行病学证据支持酒精摄入可能与结直肠癌风险增加有关。然而，大肠解剖部位的结果并不一致。我们对 1990 年至 2005 年 6 月期间发表的关于酒精摄入与结肠癌和直肠癌之间关系的前瞻性队列研究进行了荟萃分析。我们使用与最高与最低酒精摄入类别相关的相对风险（RR）荟萃分析，以及使用固定或随机效应模型（取决于研究之间效应的异质性）对研究特定剂量反应斜率进行荟萃分析，量化了与结肠癌和直肠癌的关联。包括 6,300 多名结直肠癌患者的 16 项前瞻性队列研究符合纳入条件。当比较最高和最低的酒精摄入量时，大量饮酒与结肠癌（RR = 1.50；95% CI = 1.25，1.79）和直肠癌（RR = 1.63；95% CI = 1.35，1.97）风险增加显着相关，相当于每周增加 100 克酒精摄入量，结肠癌或直肠癌风险增加 15%。这种关系因解剖部位（结肠、直肠）的不同而没有显着差异。使用荟萃回归分析，我们确定了进行研究的地理区域作为研究间效应异质性的可能来源。预防结直肠癌的生活方式建议应考虑限制酒精摄入量。 (c) 2006 Wiley-Liss, Inc.
The epidemiologic evidence support that alcohol intake might be associated with increased colorectal cancer risk. However, the results by anatomic site in the large bowel are inconsistent. We conducted a meta-analysis of prospective cohort studies published between 1990 and June 2005 on the relationship between alcohol intake and colon and rectal cancer. We quantified associations with colon and rectal cancer using meta-analysis of relative risk (RR) associated to the highest versus the lowest category of alcohol intake and meta-analysis of study-specific dose-response slopes using fixed or random effect models depending on the heterogeneity of effects among studies. Sixteen prospective cohort studies including more than 6,300 patients with colorectal cancer were eligible for inclusion. High alcohol intake was significantly associated with increased risk of colon (RR = 1.50; 95% CI = 1.25, 1.79) and rectal cancer (RR = 1.63; 95% CI = 1.35, 1.97) when comparing the highest with the lowest category of alcohol intake, equivalent to a 15% increase of risk of colon or rectal cancer for an increase of 100 g of alcohol intake per week. The relationship did not differ significantly by anatomical site (colon, rectum). Using meta-regression analysis, we identified geographical area where the study was conducted as a possible source of between-study heterogeneity of effects among studies. Lifestyle recommendations for prevention of colorectal cancer should consider limiting alcohol intake. (c) 2006 Wiley-Liss, Inc.