Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics
Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics
复制标题
DOI：
10.1152/japplphysiol.00795.2004
复制
发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Paiva, M
中科院分区：
文献类型：
--
作者：
van Ertbruggen, C;Hirsch, C;Paiva, M
我们研究了气体流动和颗粒沉积在一个现实的三维（3D）模型的支气管树，从气管延伸到节段支气管（第7代气道最远端的），使用计算流体动力学。该模型基于Horsfield等人的形态测量数据（Horsfield K，Dart G，Olson DE，Filley GF和Cumming G. J Appl Physiol 31：207 - 217，1971）以及支气管镜和计算机断层摄影图像，其给出弯曲导管的空间3D取向。它结合了连续分支平面的真实角度。模拟了在50和500 cm（3）/s之间变化的稳定吸气流量，以及球形气溶胶颗粒（1 - 7 μ m直径，1 g/cm（3）密度）的沉积。流动模拟表明，由于其相对较短的长度，在分支不完全发展的流动。与简单弯管中的流动相比，在分叉下游取一个直径的节段支气管中的速度流动剖面被扭曲，并且观察到二次流场的宽模式。两者都是由于分叉网络的不对称3D配置。将模型中的粘性压降与Pedley等人（Pedley TJ、Schroter RC和Sudlow MF. Respir Physiol 9：387 - 405，1970），其显示为良好的第一近似。颗粒沉积随颗粒尺寸增加而增加，并且对于类似于200 cm（3）/s的吸气流速，颗粒沉积最小，但是对于同代的分支，颗粒沉积高度不均匀。
We have studied gas flow and particle deposition in a realistic three-dimensional (3D) model of the bronchial tree, extending from the trachea to the segmental bronchi (7th airway generation for the most distal ones) using computational fluid dynamics. The model is based on the morphometrical data of Horsfield et al. ( Horsfield K, Dart G, Olson DE, Filley GF, and Cumming G. J Appl Physiol 31: 207 - 217, 1971) and on bronchoscopic and computerized tomography images, which give the spatial 3D orientation of the curved ducts. It incorporates realistic angles of successive branching planes. Steady inspiratory flow varying between 50 and 500 cm(3)/s was simulated, as well as deposition of spherical aerosol particles (1 - 7 mum diameter, 1 g/cm(3) density). Flow simulations indicated nonfully developed flows in the branches due to their relative short lengths. Velocity flow profiles in the segmental bronchi, taken one diameter downstream of the bifurcation, were distorted compared with the flow in a simple curved tube, and wide patterns of secondary flow fields were observed. Both were due to the asymmetrical 3D configuration of the bifurcating network. Viscous pressure drop in the model was compared with results obtained by Pedley et al. ( Pedley TJ, Schroter RC, and Sudlow MF. Respir Physiol 9: 387 - 405, 1970), which are shown to be a good first approximation. Particle deposition increased with particle size and was minimal for similar to 200 cm(3)/s inspiratory flow, but it was highly heterogeneous for branches of the same generation.