An Analysis of the Action of Proflavine on Bacteriophage Growth
An Analysis of the Action of Proflavine on Bacteriophage Growth
复制标题
丙黄素对噬菌体生长作用的分析
DOI：
10.1128/jb.56.6.795-809.1948
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发表时间：
1948
影响因子：
3.2
通讯作者：
R. A. C. Foster
中科院分区：
文献类型：
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作者：
R. A. C. Foster
细菌-噬菌体系统为研究宿主-病毒关系的一般原理提供了许多优势。用于分析噬菌体生长的精确定量方法的可用性使得该系统适合于药物抑制病毒生长的性质的研究。对噬菌体增殖具有抑制活性的大多数化合物同样显示出对细菌增殖的抑制作用（Delbruick和Luria，1943; Spizizen，1943; Bailey，1943; Jones和Schatz，1946; Cohen和安德森，1946; Cohen和Fowler，1947）。在这些情况下，抑制似乎是间接的，通过抑制宿主的代谢，可能是非特异性的。最近报道了一种相反的现象，即在青霉素的抑菌浓度下噬菌体产量增加（Price，1947）。高于宿主生长最适温度的温度以一定程度的特异性抑制噬菌体生长（Luria，1943）。Fitzgerald及其合作者（1946）曾报道过许多吖啶类化合物的特异性抑制作用和核糖核酸的抗吖啶作用。本文是关于吖啶类化合物原黄素作用的进一步研究结果，以及它们与噬菌体增殖问题有关的解释。
The bacterium-bacteriophage system offers many advantages for the study of the general principles of the host-virus relationship. The availability of precise quantitative methods for analyzing phage growth makes this system suitable for the study of the nature of the inhibition of virus growth by drugs. A majority of the compounds with suppressive activity on phage multiplication have likewise shown suppressive effects on bacterial multiplication (Delbruick and Luria, 1943; Spizizen, 1943; Bailey, 1943; Jones and Schatz, 1946; Cohen and Anderson, 1946; Cohen and Fowler, 1947). In these cases the inhibition appeared to be indirect through inhibition of the metabolism of the host, and possibly aspecific. Recently a reverse phenomenon has been reported, namely, increased yields of phage occurring at bacteriostatic concentrations of penicillin (Price, 1947). Temperatures above optimum for the growth of the host inhibit phage growth with some degree of specificity (Luria, 1943). What appears to be a specific inhibitory effect of a number of acridines and an antiacridine action of ribose nucleic acid has been reported by Fitzgerald and collaborators (1946). The present paper is concerned with the results of further studies on the action of the acridine compound proflavine and with their interpretation in relation to the problem of phage multiplication.