Cryptococcus gattii outbreak expands into the Northwestern United States with fatal consequences.
Cryptococcus gattii outbreak expands into the Northwestern United States with fatal consequences.
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DOI：
10.3410/b1-62
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发表时间：
2009-08-17
期刊：
影响因子：
--
通讯作者：
Heitman, Joseph
中科院分区：
文献类型：
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作者：
Byrnes, Edmond J;Heitman, Joseph
在过去的十年中，主要的真菌病原体格特隐球菌已经进化并适应了北美太平洋西北地区的温带气候。这种病原体现在是地方性的，是威胁生命的肺部和中枢神经系统感染的一个日益常见的原因，这些感染难以控制，在某些情况下对整个区域的人类和其他哺乳动物是致命的。最近的一系列报告提供的证据表明，进化、气候和人为因素可能导致温哥华岛暴发基因型扩展到美国，同时在俄勒冈州出现了一种独特的基因型。正在进行的研究解决了分子流行病学，交配和遗传交换的作用，以及这一前所未有的真菌感染爆发的地理起源相当大的公共卫生规模。
In the past decade, the primary fungal pathogen Cryptococcus gattii has evolved and adapted to the temperate climate of the Pacific Northwest region of North America. This pathogen is now endemic and an increasingly common cause of life-threatening pulmonary and central nervous system infections that are difficult to manage and, in some cases, fatal to humans and other mammals throughout the region. A series of recent reports provide evidence that evolutionary, climatic, and anthropogenic factors may be causing the expansion of the Vancouver Island outbreak genotype into the United States, with the concomitant emergence of a unique genotype in the state of Oregon. Ongoing studies address the molecular epidemiology, roles of mating and genetic exchange, and geographic origins of this unprecedented outbreak of fungal infection of considerable public health magnitude.