PRESENCE OF CANNABINOID BINDING-SITES IN THE BRAIN FROM EARLY POSTNATAL AGES
PRESENCE OF CANNABINOID BINDING-SITES IN THE BRAIN FROM EARLY POSTNATAL AGES
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DOI：
10.1097/00001756-199302000-00005
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发表时间：
1993-02-01
期刊：
影响因子：
1.7
通讯作者：
FERNANDEZRUIZ, JJ
中科院分区：
文献类型：
--
作者：
DEFONSECA, FR;RAMOS, JA;FERNANDEZRUIZ, JJ
目前的研究表明，大麻素受体在出生后早期的大脑中存在。在出生后早期（出生后2天和5天）的前脑和剩余脑中观察到特异性和饱和结合。女性新生儿前脑表现出较高的受体密度在出生后2天比男性，但这种趋势在5天被逆转。从出生后第10天开始，可以在更明确的脑区（即纹状体、边缘前脑和腹侧中脑）测量受体。在这三个领域的受体的个体发育是相对相似的，表现出一个渐进的增加，最大化的第30或40天，然后随后下降到成人值。在纹状体和腹侧中脑中发现了微妙的两性异形，但在边缘前脑中没有。
THE present study demonstrates the presence of cannabinoid receptors in the brain from early postnatal ages. Specific and saturable binding was observed in the forebrain and remaining brain from early postnatal ages (2 and 5 days after birth). Female neonate forebrain exhibited a higher receptor density at 2 days after birth than males, but this trend was inverted at 5 days. From postnatal day 10, the receptors could be measured in more defined brain areas, i.e. the striatum, limbic forebrain and ventral mesencephalon. The ontogeny of the receptors in these three areas was relatively similar, exhibiting a progressive increase which maximised on days 30 or 40 and then subsequently decreased to adult values. Subtle sexual dimorphism was found in the striatum and ventral mesencephalon but not the limbic forebrain.