Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults
Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults
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DOI：
10.1016/j.jpsychires.2010.02.007
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发表时间：
2010-10-01
影响因子：
4.8
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Horia, Hiroaki;Ozeki, Yuji;Kunugi, Hiroshi
心理困扰和应对方式被认为与下丘脑-垂体-肾上腺（HPA）轴的功能改变有关，尽管它们之间的关系还有很多需要了解的地方。高和低皮质醇水平（或反应性）均代表 HPA 轴功能障碍，积累的证据表明它们与不同类型的精神病理学有关。地塞米松 (DEX)/促肾上腺皮质激素释放激素 (CRH) 测试已广泛用于识别各种精神疾病（包括情绪障碍）中的 HPA 轴异常；然而，心理困扰和应对方式与 HPA 轴功能之间可能存在的关联尚未通过该测试得到充分记录。在这里，我们检查了 121 名健康志愿者中通过 DEX/CRH 测试测量的 HPA 轴反应性与主观感知的心理困扰和应对方式的关系，这两者均通过自我报告问卷进行评估。根据皮质醇抑制模式将受试者分为三组，即不完全抑制组（DST皮质醇> = 5μg/dL或DEX/CRH-皮质醇> = 5μg/dL），中度抑制组（DST皮质醇<5μg/dL和1μg/dL）
Psychological distress and coping styles have been suggested to relate to altered function in the hypothalamic-pituitary-adrenal (HPA) axis, although there remains much to be understood about their relationships. High and low cortisol levels (or reactivity) both represent HPA axis dysfunction, with accumulated evidence suggesting that they are linked to different types of psychopathology. The dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test has been extensively used to identify HPA axis abnormalities in various psychiatric conditions including mood disorders; however, the possible associations of psychological distress and coping styles with HPA axis function have not been well documented using this test. Here, we examined the relationships of HPA axis reactivity as measured by the DEX/CRH test with subjectively perceived psychological distress and coping styles, both of which were assessed with self-report questionnaires, in 121 healthy volunteers. Subjects were divided into three groups by the cortisol suppression pattern, namely the incomplete-suppressors (DSTCortisol >= 5 mu g/dL or DEX/CRH-Cortisol >= 5 mu g/dL), moderate-suppressors (DST-Cortisol < 5 mu g/dL and 1 mu g/dL