A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force.
A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force.
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啮齿动物癫痫模型中生理数据的临床前通用数据元素的伴随。
DOI：
10.1002/epi4.12261
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发表时间：
2018
期刊：
影响因子：
3
通讯作者：
Nehlig,Astrid
中科院分区：
文献类型：
--
作者：
Gorter,JanA;vanVliet,ErwinA;Dedeurwaerdere,Stefanie;Buchanan,GordonF;Friedman,Daniel;Borges,Karin;Grabenstatter,Heidi;Lukasiuk,Katarzyna;Scharfman,HelenE;Nehlig,Astrid
国际抗癫痫联盟/美国癫痫学会（ILAE/AES）联合翻译工作组创建了TASK 3工作组，以验证临床前癫痫研究各个方面的通用数据元素（CDE），这有助于提高实验设计的标准化。本文涉及的参数，可以测量，以评估用于研究癫痫啮齿动物模型的动物的生理状况。在这里，我们讨论CDE测量成年大鼠和小鼠的生理参数，如一般健康状况，温度，心脏和呼吸功能，血液成分。我们提供了详细的CDE表格和病例报告表（CRF），并与此配套手稿一起讨论了动物生理学不同方面的监测。CDE、CRF和配套论文可供所有研究人员使用，它们的使用将有利于转化临床前癫痫研究的协调性和可比性。最终的希望是促进生物标志物和癫痫新疗法的发展。
The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3 working groups to createcommon data elements (CDEs)for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs. This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDEs for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.