CBCT evaluation of buccal bone regeneration in postmenopausal women with and without osteopenia or osteoporosis undergoing dental implant therapy.
CBCT evaluation of buccal bone regeneration in postmenopausal women with and without osteopenia or osteoporosis undergoing dental implant therapy.
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CBCT 评估接受牙种植治疗的患有或不患有骨质减少或骨质疏松症的绝经后妇女的颊骨再生。
DOI：
10.1016/j.prosdent.2015.02.015
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Freilich,Martin
中科院分区：
文献类型：
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作者：
Tadinada,Aditya;Ortiz,Denise;Taxel,Pamela;Shafer,David;Rengasamy,Kandasamy;Pendrys,David;Freilich,Martin
由于骨质疏松/骨质减少妇女的牙槽骨增强术预后不确定，因此应采用客观可靠的方法来研究标准手术入路。目的：本临床研究的目的是通过锥形束计算机断层扫描（CBCT）评估骨增强和植入9个月后不同水平的全身骨骼健康的绝经后妇女的骨再生，并测试这种测量方法的概念证明。材料和方法对14名绝经后妇女接受植牙和同时水平隆牙的最佳实践研究进行了分析。根据术前双能x线骨密度测定结果，将女性分为骨质减少/骨质疏松或正常。所有种植研究部位均接受颗粒移植物和/或颊板扩张。术前、术后即刻和术后9个月分别用CBCT评估研究部位。所有分析均采用非参数统计。采用相关样本Wilcoxon符号秩检验评估时间点间骨宽度的差异（所有检验的α= 0.05）。结果9个月后，与术前基线测量值相比，14名参与者中有13名显示骨宽度增加。骨质疏松/骨质减少患者的增加有统计学意义（P=.007），而骨骼健康正常的患者则无统计学意义（P=.066）。CBCT扫描显示种植体颊部矿化组织具有成熟骨的x线表现。结论scbct显示骨再生的证据，绝经后骨质减少/骨质疏松妇女在手术重建后牙槽嵴宽度增加。
Statement of problemBecause alveolar bone augmentation in women with osteoporosis/osteopenia has an uncertain prognosis, objective and reliable methods should be used to study standard surgical approaches.PurposeThe purpose of this clinical study was to evaluate bone regeneration 9 months after bone augmentation and implant placement in postmenopausal women with different levels of systemic bone health by using cone beam computed tomography (CBCT) and to test proof of concept for this measurement approach.Material and methodsA subset of 14 participants was analyzed in a best practice study of postmenopausal women receiving dental implants and simultaneous horizontal ridge augmentation. Women were categorized as osteopenic/osteoporotic or normal based on the results of preoperative dual-energy x-ray absorptiometry. All implant study sites received a particulate graft and/or buccal plate expansion. The study sites were evaluated with CBCT preoperatively, immediately postoperatively, and 9 months postoperatively. Nonparametric statistics were used for all analyses. The related samples Wilcoxon signed rank test was used to assess the differences in bone width between time points (α=.05 for all tests).ResultsAfter 9 months, 13 out of 14 participants showed increased bone width compared to the preoperative baseline measurements. The increase was statistically significant for the participants with osteoporosis/osteopenia (P=.007), but not for those with normal bone health (P=.066). The CBCT scans showed that mineralized tissue buccal to the implant surface had the radiographic appearance of mature bone.ConclusionsCBCT showed evidence of bone regeneration, with an increase in alveolar ridge width in postmenopausal osteopenic/osteoporotic women subsequent to surgical reconstruction.