Characterization of Retinal Functionality at Different Eccentricities in a Diurnal Rodent
Characterization of Retinal Functionality at Different Eccentricities in a Diurnal Rodent
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DOI：
10.3389/fncel.2018.00444
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发表时间：
2018-12-03
影响因子：
5.3
通讯作者：
Palacios, Adrian G.
中科院分区：
文献类型：
--
作者：
Escobar, Maria-Jose;Reyes, Cesar;Palacios, Adrian G.
虽然处理视野的中央和周边区域的视觉系统的神经元的特性已经在视觉皮层和LGN中被广泛研究，但是它们对于视网膜几乎没有被记录。视网膜是整合光学信号的第一步，尽管在功能上表征不同类型的视网膜神经节细胞（RGC）方面做出了相当大的努力，但仍然需要对具有中央视野与外周视野的细胞的特定功能进行清楚的说明。在这里，我们使用的电生理记录，收集从视网膜的昼夜啮齿类动物的dendon degus，显示与周边感受野（RF）的RGCs更大，更快，并有更短的瞬态响应。当与具有更多中心RE的RGC相比时，这转化为在高时间频率和全频率带宽处的更高灵敏度。我们还观察到ON和OFF细胞群之间的不平衡与偏心率保持一致。最后，RGCs功能类型的高度多样性突出了在视觉处理的早期阶段实施的计算策略的复杂性，这可能会激发仿生人工系统的发展。
Although the properties of the neurons of the visual system that process central and peripheral regions of the visual field have been widely researched in the visual cortex and the LGN, they have scarcely been documented for the retina. The retina is the first step in integrating optical signals, and despite considerable efforts to functionally characterize the different types of retinal ganglion cells (RGCs), a clear account of the particular functionality of cells with central vs. peripheral fields is still wanting. Here, we use electrophysiological recordings, gathered from retinas of the diurnal rodent Octodon degus, to show that RGCs with peripheral receptive fields (RF) are larger, faster, and have shorter transient responses. This translates into higher sensitivity at high temporal frequencies and a full frequency bandwidth when compared to RGCs with more central RE. We also observed that imbalances between ON and OFF cell populations are preserved with eccentricity. Finally, the high diversity of functional types of RGCs highlights the complexity of the computational strategies implemented in the early stages of visual processing, which could inspire the development of bio-inspired artificial systems.