Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men
Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men
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DOI：
10.1007/s00234-005-0004-9
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发表时间：
2006-01-01
期刊：
影响因子：
2.8
通讯作者：
Senf, W
中科院分区：
文献类型：
--
作者：
Gizewski, ER;Krause, E;Senf, W
先前关于空间和语言任务期间功能成像的性别差异的研究尚无定论。此外，在女性中，与月经周期的其余时间相比，这种差异可能发生在黄体中期。为了进一步检查性别差异，在心理旋转和动词生成测试中，对 12 名男性志愿者和 12 名女性志愿者（黄体中期）进行了功能性 MRI 测试。特定感兴趣区域 (ROI) 的未校正 P 值 < 0.001 的双样本 t 检验揭示了两种刺激中的大脑激活差异。在心理旋转测试中，右侧内侧额叶、中央前部和双侧顶下皮质的激活水平较高，而女性的激活水平则发生在右侧颞下和内侧、右侧额叶上皮质和左侧梭状回。在动词生成测试中，发现男性左侧内侧颞叶和中央前皮层的激活水平较高。我们的结果表明，在黄体中期，男性和女性在认知任务期间的大脑活动存在差异。执行心理旋转任务时的性别差异比动词生成任务时更加突出。
Previous studies of gender-specific differences in functional imaging during spatial and language tasks have been inconclusive. Furthermore, among women, such differences may occur during mid-luteal phase compared to the rest of the menstrual cycle. In order to examine further gender differences, functional MRI was performed in 12 male volunteers and 12 female volunteers (in the mid-luteal phase) during mental rotation and verb-generation tests. Two-sample t-tests with uncorrected P values of < 0.001 for the specific regions of interest (ROIs) revealed cerebral activation differences in both stimuli. During mental rotation tests, higher levels of activation were noted in the right medial frontal, precentral, and bilateral inferior parietal cortex, while in women this occurred in the right inferior and medial temporal, right superior frontal cortex, and left fusiform gyrus. During verb-generation tests, higher levels of activation in men was found in the left medial temporal and precentral cortex. Our results indicate that differences in cerebral activity during cognitive tasks can be shown between men and women in the mid-luteal phase. Gender differences while performing a mental rotation task were more prominent than during a verb-generation task.