Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy
Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy
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DOI：
10.1016/j.ejca.2012.11.032
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发表时间：
2013-05-01
影响因子：
8.4
通讯作者：
Zhang, Y. P.
中科院分区：
文献类型：
--
作者：
Jin, Y.;Ye, X.;Zhang, Y. P.
背景与目的：转移性鼻咽癌（NPC）患者的生存结局在个体之间存在显著差异。本研究旨在探讨血清乳酸脱氢酶（S-LDH）水平对预测鼻咽癌转移患者的临床疗效和生存结局的临床价值。结果：治疗前S-LDH升高（> 245 IU/L）的患者生存率明显低于治疗前S-LDH正常者（P <0.05），治疗后S-LDH升高（>245 IU/L）的患者生存率明显低于治疗前S-LDH正常者（P <0.05），治疗后S-LDH升高（>245 IU/L）的患者生存率明显低于治疗前S-LDH正常者（P <0.05）。
Background and objective: The survival outcomes of patients with metastatic nasopharyngeal carcinoma (NPC) differ significantly between individuals. This study aimed to evaluate whether serum lactic dehydrogenase (S-LDH) level had a clinical value in predicting clinical response and survival outcome for patients with metastatic NPC.Methods: S-LDH level was measured at baseline and then before every cycle of treatment in 689 NPC patients with distant metastases. Correlations of pre-treatment and post-treatment S-LDH levels to response of treatment and survival were analysed retrospectively.Results: Patients with elevated values of pre-treatment S-LDH (>245 IU/L) had significantly worse survival than those with normal values of pre-treatment S-LDH (