Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value.
Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value.
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基于聚甲基丙烯酰胺结构的超灵敏（共）聚合物，具有精细可调的 pH 响应值
DOI：
10.3390/molecules23081870
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发表时间：
2018-07-27
期刊：
影响因子：
--
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Fan H;Li P;Li W;Li H;Huang X
以甲基丙烯酸2-（二烷基氨基）乙酯为单体，通过自由基聚合制备了新型的pH响应性叔胺共聚物。这些聚合物是pH敏感的，具有在水溶液中响应微调的能力，这通过滴定、透射率测量和质子核磁共振光谱来证明。聚合物在低pH值下可溶于水，由胺基之间的静电排斥引起，并且由于烷基的疏水作用而在其pKa值以上聚集。通过增加疏水单体的比例，将pH响应值从7.4精确地调谐到4.8。我们的工作提供了一种新的方法，为开发超灵敏的pH响应聚合物在生物医学材料中的应用。
Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials.
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影响因子：
16.1
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1016/j.ejpb.2017.05.002
发表时间：
2017-08-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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