Hair Cortisol Concentrations in Opioid-Exposed versus Nonexposed Mother-Infant Dyads.
Hair Cortisol Concentrations in Opioid-Exposed versus Nonexposed Mother-Infant Dyads.
复制标题
暴露于阿片类药物与未暴露于阿片类药物的母婴二人组的头发皮质醇浓度。
DOI：
10.1055/s-0043-1778008
复制
发表时间：
2023
影响因子：
2
通讯作者：
Wachman,ElishaM
中科院分区：
文献类型：
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作者：
Morrison,TierneyM;Schiff,DavidaM;Olson,Abigael;Hunter,RichardG;Agarwal,Joel;Work,ErinC;Muftu,Serra;Shrestha,Hira;Boateng,Jeffery;Werler,MarthaM;Carter,Ginny;Jones,HendreeE;Wachman,ElishaM
目的试点测量头发皮质醇浓度（HCC）在孕妇与阿片类药物使用障碍和他们的婴儿随着时间的推移，并研究头发皮质醇作为慢性stressinthis population.Study DesignIn生物标志物的潜在效用在这个试点前瞻性队列研究的母婴二对与产前阿片类药物暴露，我们获得了母婴HCC在分娩和产后1至3个月内再次。肝细胞癌阿片类药物和对照组之间进行了比较，两个时间点之间。ResultsThere阿片类药物和对照组产妇或婴儿肝细胞癌在任何时间点之间没有显着差异。然而，在阿片类药物暴露组中，两个时间点的婴儿HCC显著增加。ConclusionThis pilot study describes our experience with measurement of HCC in opioid exposed mother-infant dyads.关键点
ObjectiveTo pilot measurement of hair cortisol concentration (HCC) in pregnant women with opioid use disorder and their infants over time and study the potential utility of hair cortisol as a biomarker of chronic stress in this population.Study DesignIn this pilot prospective cohort study of mother–infant dyads with and without prenatal opioid exposure, we obtained mother–infant HCCs at delivery and again within 1 to 3 months' postpartum. HCCs were compared between the opioid and control groups and between the two time points.ResultsThere were no significant differences between opioid and control group maternal or infant HCCs at either time point. However, within the opioid-exposed group, there was a significant increase in infant HCCs across the two time points.ConclusionThis pilot study describes our experience with the measurement of HCCs in opioid-exposed mother–infant dyads.Key Points