Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.
Hypalgesia effect of IL-24, a quite new mechanism for IL-24 application in cancer treatment.
复制标题
IL-24的痛觉减退作用，是IL-24应用于癌症治疗的一个全新机制。
DOI：
10.1089/jir.2012.0146
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发表时间：
2013-10
影响因子：
2.3
通讯作者：
Yang, Jicheng
中科院分区：
文献类型：
--
作者：
Zhao, Yaodong;Tian, Li;Sheng, Weihua;Miao, Jingcheng;Yang, Jicheng
肿瘤抑制性黑色素瘤分化相关基因7/白细胞介素24（mda-7/IL-24）已被广泛认为是一种抑癌基因，但IL-24作为IL-10家族的一员，是否参与癌痛的发生尚未见报道。本研究通过将5×103个步行者256大鼠乳腺癌腹水瘤细胞注射到大鼠胫骨骨髓腔内建立动物模型，发现腺病毒介导的IL-24可显著提高手术侧和对侧足底机械痛阈; IL-24还可通过诱导细胞凋亡抑制体外培养的步行者256细胞的生长。在病理上，IL-24可保护骨小梁和皮质骨不被完全破坏。酶联免疫吸附试验（ELISA）结果显示，IL-24处理可使动物血浆β-内啡肽水平升高，IL-6浓度降低。我们的研究表明IL-24不仅通过抑制肿瘤增殖，而且通过促进β-内啡肽的合成，抑制IL-6的分泌来缓解癌痛，对癌症具有潜在的治疗作用。
Tumor suppressor melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) has been extensively regarded as an anti-oncogene; however, that whether IL-24, as a member of IL-10 family, is involved in cancer pain was seldom reported before. In this study, we found that IL-24 mediated by adenovirus could significantly increase the plantar mechanical pain threshold in both operation side and contralateral side of the animal models, which were established by injecting 5×103 Walker 256 rat breast cancer ascitic tumor cells into rats' tibia bone medullary canals; IL-24 could also suppress in vitro Walker 256 cells growth by inducing cell apoptosis. Pathologically, IL-24 could protect bone trabecula and substantia corticalis ossium from being completely destructed. Enzyme-linked immunosorbent assay (ELISA) showed that IL-24 treatment could increase the β-endorphin levels and decrease the IL-6 concentration in plasma of animals. Our study indicated that IL-24 has a potential treatment effect on cancers not only by inhibiting tumor proliferation, but also by the promotion of β-endorphin synthesis, inhibition of IL-6 secretion to relieve cancer pain.
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影响因子：
5.1
作者：
M. Pohl;D. Fink
通讯作者：
M. Pohl;D. Fink
影响因子：
6.4
作者：
Y. Zhu;H. Lv;Y. Xie;W. Sheng;J. Xiang;J. Yang
通讯作者：
Y. Zhu;H. Lv;Y. Xie;W. Sheng;J. Xiang;J. Yang
影响因子：
2.1
作者：
BONICA, JJ
通讯作者：
BONICA, JJ
影响因子：
4.4
作者：
Caudell, EG;Mumm, JB;Grimm, EA
通讯作者：
Grimm, EA
影响因子：
2.5
作者：
N. Rasmussen;L. Farr
通讯作者：
N. Rasmussen;L. Farr