DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data
DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data
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DOI：
10.1093/nar/gkh371
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发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Wallace, BA
中科院分区：
文献类型：
--
作者：
Whitmore, L;Wallace, BA
DICHROWEB网络服务器能够在线分析圆二色谱(CD)光谱数据，提供计算的二级结构含量和比较计算结构和实验数据的图形分析。该服务器位于http://www.cryst.bbk.ac.uk/cdweb，可以通过密码受限的用户ID访问，该ID在完成注册表后可用。该服务器以用户友好的方式接受各种格式的数据，包括商用CD仪器和基于同步辐射的圆二向色性光束线输出的数据，以及光谱处理软件包产生的数据，从而便于使用五种流行算法和(目前)七种不同的参考数据库进行分析。它产生作为输出计算的二级结构，用于分析的拟合度参数，以及实验光谱、计算光谱和差谱的表格和图形显示。与服务器相关的网页提供关于CD光谱方法和术语、文献参考文献和用于解释分析结果的辅助工具的信息。
The DICHROWEB web server enables on-line analyses of circular dichroism (CD) spectroscopic data, providing calculated secondary structure content and graphical analyses comparing calculated structures and experimental data. The server is located at http://www.cryst.bbk.ac.uk/cdweb and may be accessed via a password-limited user ID, available upon completion of a registration form. The server facilitates analyses using five popular algorithms and (currently) seven different reference databases by accepting data in a user-friendly manner in a wide range of formats, including those output by both commercial CD instruments and synchrotron radiation-based circular dichroism beamlines, as well as those produced by spectral processing software packages. It produces as output calculated secondary structures, a goodness-of-fit parameter for the analyses, and tabular and graphical displays of experimental, calculated and difference spectra. The web pages associated with the server provide information on CD spectroscopic methods and terms, literature references and aids for interpreting the analysis results.