Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion.
Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion.
复制标题
白细胞介素 I 和肾小球系膜。
作者：
D. Lovett;K. Resch;D. Gemsa
单核细胞(MC)浸润是许多形式的免疫介导性肾小球肾炎的显著特征。单核/巨噬细胞通过释放白介素1(IL-1)诱导系膜细胞增殖，并刺激肾小球基底膜降解中性蛋白酶的分泌。此外，系膜细胞释放一种细胞因子，表达单核细胞IL-1的许多生物学特性，包括刺激系膜细胞增殖。由于IL-1的许多作用是通过诱导前列腺素(PG)合成介导的，因此作者测定了纯化的巨噬细胞和系膜IL-1对前列腺素E(PGE)、前列环素和血栓素分泌的影响。结果表明，在纯化的IL-1作用下，循环系膜细胞主要释放PGE。在肾小球炎症过程中，单核细胞或系膜细胞局部释放IL-1，随后系膜细胞产生扩张血管的前列腺素E，这可能是这些疾病中观察到的肾小球微循环改变的部分原因。
Monocytic (MC) infiltration is a prominent feature of many forms of immune-mediated glomerulonephritis. Through the release of interleukin-1, (IL-1), monocyte/macrophages have been shown to induce the proliferation of mesangial cells and to stimulate the secretion of a glomerular basement membrane-degrading neutral proteinase. In addition, mesangial cells release a cytokine that expresses many of the biologic properties of monocyte IL-1, including stimulation of mesangial cell proliferation. Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane. The results indicated that cycling MCs release primarily PGE in response to purified IL-1. The local release by either monocytes or mesangial cells of IL-1 during glomerular inflammation, with subsequent mesangial cell generation of vasodilatory PGE, may be responsible in part for the alterations in the glomerular microcirculation observed in these disorders.