Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder.
Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder.
复制标题
儿童期滥用对重度抑郁症患者抑郁症状的直接和间接影响。
DOI：
10.1186/s12888-015-0636-1
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发表时间：
2015-10-14
期刊：
影响因子：
4.4
通讯作者：
Yamawaki S
中科院分区：
文献类型：
--
作者：
Hayashi Y;Okamoto Y;Takagaki K;Okada G;Toki S;Inoue T;Tanabe H;Kobayakawa M;Yamawaki S
众所周知，重度抑郁症的发病、进展和预后受到多种因素相互作用的影响。这项研究调查了童年虐待、性格和生活事件的压力如何与抑郁症患者的抑郁症状相关。重度抑郁症患者（N=113，58 名女性和 55 名男性）完成了贝克抑郁量表 II (BDI-II)、神经质外向性开放性五因素量表 (NEO-FFI)、儿童虐待和创伤量表 (CATS) 以及生活经历调查 (LES)，这些都是自我报告量表。使用 SPSS AMOS 21.0 对结果进行相关分析和结构方程建模 (SEM) 分析。童年虐待直接预测抑郁症的严重程度，并通过人格的中介间接预测抑郁症的严重程度。 LES 的负生活变化评分受到童年虐待的影响，但它并不能预测抑郁症的严重程度。这项研究首次报告了抑郁症患者的童年虐待、性格、成年生活压力和抑郁严重程度之间的关系。童年虐待直接或间接预测了抑郁症的严重程度。这些结果表明临床医生需要接受抑郁症患者童年时期遭受虐待的可能性。 SEM 是用于假设建模而非因果建模的过程。因此，不能排除开发包含其他变量的更合适模型的可能性。
It is known that the onset, progression, and prognosis of major depressive disorder are affected by interactions between a number of factors. This study investigated how childhood abuse, personality, and stress of life events were associated with symptoms of depression in depressed people. Patients with major depressive disorder (N = 113, 58 women and 55 men) completed the Beck Depression Inventory-II (BDI-II), the Neuroticism Extroversion Openness Five Factor Inventory (NEO-FFI), the Child Abuse and Trauma Scale (CATS), and the Life Experiences Survey (LES), which are self-report scales. Results were analyzed with correlation analysis and structural equation modeling (SEM), by using SPSS AMOS 21.0. Childhood abuse directly predicted the severity of depression and indirectly predicted the severity of depression through the mediation of personality. Negative life change score of the LES was affected by childhood abuse, however it did not predict the severity of depression. This study is the first to report a relationship between childhood abuse, personality, adulthood life stresses and the severity of depression in depressed patients. Childhood abuse directly and indirectly predicted the severity of depression. These results suggest the need for clinicians to be receptive to the possibility of childhood abuse in patients suffering from depression. SEM is a procedure used for hypothesis modeling and not for causal modeling. Therefore, the possibility of developing more appropriate models that include other variables cannot be excluded.