Genome-wide DNA methylation profiling shows molecular heterogeneity of anaplastic pleomorphic xanthoastrocytoma
Genome-wide DNA methylation profiling shows molecular heterogeneity of anaplastic pleomorphic xanthoastrocytoma
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DOI：
10.1111/cas.13903
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发表时间：
2019-02-01
期刊：
影响因子：
5.7
通讯作者：
Ichimura, Koichi
中科院分区：
文献类型：
--
作者：
Nakamura, Taishi;Fukuoka, Kohei;Ichimura, Koichi
在2016年修订的世界卫生组织分类中，间变性多形性黄色星形细胞瘤(PXA)被新定义为PXA实体的变体。此外，一些间变性PXA的预后极差，这显示出一种儿童胶质母细胞瘤(GBM)的分子特征。最近对原发性中枢神经系统肿瘤的综合分子分类提出了组织学和分子特征之间的一些差异。在这里，在全基因组的分子分析中，我们展示了一种极具侵袭性的间变性PXA，它导致了儿科GBM的分子图谱。分子生物学方法的全面实施是预测间变性PXA预后和决定治疗策略的关键。
In the revised World Health Organization classification 2016, anaplastic pleomorphic xanthoastrocytoma (PXA) has been newly defined as a variant of the PXA entity. Furthermore, some anaplastic PXA were reported to have extremely poor prognosis which showed a type of pediatric glioblastoma (GBM) molecular profile. Recent integrated molecular classification for primary central nervous system tumors proposed some differences between histological and molecular features. Herein, in a genome-wide molecular analysis, we show an extreme aggressive anaplastic PXA that resulted in a pediatric GBM molecular profile. A full implementation of the molecular approach is the key to predict prognosis and decide the treatment strategy for anaplastic PXA.