Osteopontin as a Biomarker in Chronic Kidney Disease.
Osteopontin as a Biomarker in Chronic Kidney Disease.
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DOI：
10.3390/biomedicines11051356
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发表时间：
2023-05-04
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
骨桥蛋白（Osteopontin， OPN）是一种普遍表达的蛋白，具有广泛的生理功能，包括骨矿化、免疫调节和伤口愈合。OPN与多种形式的慢性肾脏疾病（CKD）的发病机制有关，其中它促进炎症和纤维化并调节钙和磷酸盐代谢。慢性肾病患者，特别是糖尿病肾病和肾小球肾炎患者的肾脏、血液和尿液中OPN表达增加。全长OPN蛋白被凝血酶、基质金属蛋白酶(MMP)-3、MMP-7、组织蛋白酶- d和纤溶酶等多种蛋白酶切割，产生n端OPN (ntOPN)，这可能在CKD中有更不利的影响。研究表明，OPN可能作为CKD的生物标志物，虽然需要更多的研究来充分评估和验证OPN和ntOPN作为CKD的生物标志物，但现有的证据表明，它们是有希望进一步研究的候选者。针对OPN可能是一种潜在的治疗策略。多项研究表明，抑制OPN的表达或活性可以减轻肾损伤，改善肾功能。除了对肾功能的影响外，OPN还与心血管疾病有关，这是CKD患者发病和死亡的主要原因。
Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic kidney disease (CKD) where it promotes inflammation and fibrosis and regulates calcium and phosphate metabolism. OPN expression is increased in the kidneys, blood, and urine of patients with CKD, particularly in those with diabetic kidney disease and glomerulonephritis. The full-length OPN protein is cleaved by various proteases, including thrombin, matrix metalloproteinase (MMP)-3, MMP-7, cathepsin-D, and plasmin, producing N-terminal OPN (ntOPN), which may have more detrimental effects in CKD. Studies suggest that OPN may serve as a biomarker in CKD, and while more research is needed to fully evaluate and validate OPN and ntOPN as CKD biomarkers, the available evidence suggests that they are promising candidates for further investigation. Targeting OPN may be a potential treatment strategy. Several studies show that inhibition of OPN expression or activity can attenuate kidney injury and improve kidney function. In addition to its effects on kidney function, OPN has been linked to cardiovascular disease, which is a major cause of morbidity and mortality in patients with CKD.
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影响因子：
3.8
作者：
Huang J;Hu M;Niu H;Wang J;Si Y;Cheng S;Ding W
通讯作者：
Ding W
影响因子：
3.9
作者：
Bertelli, Roberta;Bonanni, Alice;Ghiggeri, G. M.
通讯作者：
Ghiggeri, G. M.
影响因子：
5.2
作者：
Deng Y;Li N;Wu Y;Wang M;Yang S;Zheng Y;Deng X;Xiang D;Zhu Y;Xu P;Zhai Z;Zhang D;Dai Z;Gao J
通讯作者：
Gao J
影响因子：
3.3
作者：
BROWN, LF;BERSE, B;SENGER, DR
通讯作者：
SENGER, DR
影响因子：
2.9
作者：
Druck, Aleksander;Patel, Dimpi;Fareed, Jawed
通讯作者：
Fareed, Jawed