Fabrication of piezoelectric porous BaTiO3scaffold to repair large segmental bone defect in sheep
Fabrication of piezoelectric porous BaTiO3scaffold to repair large segmental bone defect in sheep
复制标题
压电多孔BaTiO(3)支架的制作修复羊大节段骨缺损
DOI：
10.1177/0885328220942906
复制
发表时间：
2020-07-13
影响因子：
2.9
通讯作者：
Guo, Zheng
中科院分区：
文献类型：
--
作者：
Liu, Wenwen;Yang, Di;Guo, Zheng
Porous titanium scaffolds can provide sufficient mechanical support and bone growth space for large segmental bone defect repair. However, they fail to restore the physiological environment of bone tissue. Barium titanate (BaTiO3) is considered a smart material that can produce an electric field in response to dynamic force. Low-intensity pulsed ultrasound stimulation (LIPUS), as a kind of micromechanical wave, can not only promote bone repair but also induce BaTiO(3)to generate an electric field. In our studies, BaTiO(3)was coated on porous Ti6Al4V and LIPUS was externally applied to observe the influence of the piezoelectric effect on the repair of large bone defects in vitro and in vivo. The results show that the piezoelectric effect can effectively promote the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro as well as bone formation and growth into implants in vivo. This study provides an optional alternative to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and osseointegration for the repair of large bone defects.
