Selenite and Ca2+ homeostasis in the rat lens: effect on Ca-ATPase and passive Ca2+ transport.
Selenite and Ca2+ homeostasis in the rat lens: effect on Ca-ATPase and passive Ca2+ transport.
复制标题
大鼠晶状体中的亚硒酸盐和 Ca2 稳态：对 Ca-ATP 酶和被动 Ca2 运输的影响。
作者：
Zaiqi Wang;G. E. Bunce;J. L. Hess
Calcium permeability was significantly increased in lenses from rats 36 h following a single injection of a cataractogenic dose of sodium selenite (30 nmol/g body weight) and this permeability returned to control values by 72 h post-injection (PI). The greater Ca2+ permeability could be partially reversed by incubating lenses in medium containing 2 mM dithiothreitol (DTT). Estimations of Ca-ATPase activity revealed the greatest level occurred in the epithelial layer and that the nucleus had no detectable activity. By 48 h PI both Ca(2+)-pump activity and the Ca(2+)-dependent ATP hydrolytic activity were less compared to controls in membrane preparations from rat lenses. Only the hydrolytic activity could be partially restored by treatment with 5 mM DTT. Both permeability and active Ca2+ transport were affected by selenite in a manner that would lead to increased Ca2+ accumulation in lenses from rats treated with selenite. It is suggested that the oxidative damage that accompanies in vivo exposure to selenite could affect Ca2+ homeostasis in the lens by directly altering permeability and Ca-ATPase.
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影响因子：
2
作者：
Wang,Z;Hess,JL;Bunce,GE
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DOI：
10.1152/ajpcell.1991.260.4.c731
发表时间：
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期刊：
The American journal of physiology
影响因子：
--
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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