INVITRO INTERACTIONS BETWEEN ENDOGENOUS POLYAMINES AND SUPEROXIDE ANION
INVITRO INTERACTIONS BETWEEN ENDOGENOUS POLYAMINES AND SUPEROXIDE ANION
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DOI：
10.1007/bf01964964
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发表时间：
1986-08-01
期刊：
影响因子：
--
通讯作者：
LEWIS, DA
中科院分区：
文献类型：
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作者：
KAFY, AML;HAIGH, CG;LEWIS, DA
具有抗炎活性的内源性多胺清除由黄嘌呤氧化酶或受刺激的多形核白细胞产生的超氧化物和可能的其他氧自由基。与受刺激细胞孵育的多胺部分被代谢掉。腐胺被转化为代谢物，初步鉴定为。γ。-氨基丁醛，-鹿蹄碱和- γ。氨基丁酸酸。对亚精胺、精胺和尸胺的代谢研究并不广泛，但在tic板上形成了对希夫斯试剂呈阳性反应的代谢物。讨论了这些结果与多胺抗炎作用的可能相关性。
Endogenous polyamines with anti-inflammatory activity scavenge superoxide and possibly other oxy-radicals produced by xanthine oxidase or from stimulated polymorphonuclear leucocytes. Polyamines incubated with stimulated cells are in part metabolised. Putrescine is converted to metabolites tentatively identified as .gamma.-aminobutyraldehyde, .delta.''-pyrolline and .gamma.-aminobutyric acid. The metabolism of spermidine, spermine and cadaverine was not as extensively studied but metabolites were formed that gave positive reaction to Schiffs reagent on tic plates. The possible relevance of the results to the anti-inflammatory action of polyamines is discussed.