Treatment of Cytomegalovirus Retinitis With Cytomegalovirus-Specific T-Lymphocyte Infusion
Treatment of Cytomegalovirus Retinitis With Cytomegalovirus-Specific T-Lymphocyte Infusion
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DOI：
10.3928/23258160-20150101-14
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发表时间：
2015-01-01
影响因子：
1
通讯作者：
Kiss, Szilard
中科院分区：
文献类型：
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作者：
Gupta, Mrinali Patel;Coombs, Peter;Kiss, Szilard
巨细胞病毒(CMV)视网膜炎是一种潜在的致盲感染，影响免疫受损的患者，这些患者无法产生针对该生物体的T细胞反应。输注CMV特异性白细胞已被证明对系统性CMV感染患者有效，尤其是那些对标准治疗耐药的患者。作者报道了一例巨细胞病毒血症伴进行性视网膜炎的患者，仅输注第三方供体来源的巨细胞病毒pp65特异性T细胞就能促进巨细胞病毒视网膜炎的缓解。此病例提示巨细胞病毒特异性白细胞输注在巨细胞病毒视网膜炎治疗中的潜在作用，特别是在抗病毒治疗耐药或难治的病例中。
Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.