Goitre prevalence and thyroid abnormalities at ultrasonography:: a comparative epidemiological study in two regions with slightly different iodine status
Goitre prevalence and thyroid abnormalities at ultrasonography:: a comparative epidemiological study in two regions with slightly different iodine status
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DOI：
10.1046/j.1365-2265.2000.01121.x
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发表时间：
2000-10-01
影响因子：
3.2
通讯作者：
Perrild, H
中科院分区：
文献类型：
--
作者：
Knudsen, N;Bülow, I;Perrild, H
目的严重碘缺乏和地方性甲状腺肿之间的联系已经建立，但关于轻度碘缺乏和甲状腺肿患病率之间的关系的信息很少。对象在丹麦两个地区进行的比较流行病学研究中，我们检查了4649名来自普通人群的受试者，女性年龄18-65岁，男性年龄60-65岁。方法所有参与者进行甲状腺超声检查和触诊。在偶然的尿液样本中测量碘排泄。以前的甲状腺疾病检测问卷调查，个人访谈和跟踪records.Results的中位数碘排泄量为61 μ g/L（轻度碘缺乏症（ID））和45 μ g/L（中度ID）在这两个地区。超声检查甲状腺体积中位数分别为11.9 ml（轻度ID）和13.6 ml（中度ID），P < 0.001，甲状腺肿大分别为15.0%（轻度ID）和22.6%（中度ID），P < 0.001。两个地区的甲状腺肿患病率在40-45岁年龄组都随着年龄的增长而增加，但在40-45岁年龄组之后则没有增加。从中度ID地区转移到轻度ID地区的受试者与永久留在轻度ID地区的受试者的甲状腺肿大患病率相同。在超声检查中，两个区域的甲状腺结节均为30%，但结节较大，且在中度ID区域更常可触及。甲状腺肿大率轻度为9.8%，中度为14.6%，P < 0.001。甲状腺异常的最大区域差异被发现在moments.CONCLUSION显着差异甲状腺异常的患病率被发现在这些地区与碘排泄的适度差异。
OBJECTIVE The association between severe iodine deficiency and endemic goitre is well established, but little information is available on the relation between milder degrees of iodine deficiency and goitre prevalence.SUBJECTS In a comparative epidemiological study performed in two regions in Denmark, we examined 4649 subjects from the general population, women aged 18-65 years and men aged 60-65 years.METHODS Ultrasonography and palpation of the thyroid was performed in all participants. Iodine excretion was measured in casual urine samples. Previous thyroid disease was detected by questionnaires, personal interviews and tracing of records.RESULTS The median iodine excretion was 61 mu g/l (mild iodine deficiency (ID)) and 45 mu g/l (moderate ID) in the two regions. Median thyroid volume at ultrasonography was 11.9 ml (mild ID) and 13.6 ml (moderate ID), P < 0.001, and thyroid enlargement was found in 15.0% (mild ID) and 22.6% (moderate ID), P < 0.001. Goitre prevalence increased in both regions with age to the age group 40-45 years, but not after that age. Subjects who had moved from the moderate ID to the mild ID area had the same prevalence of thyroid enlargement as the subjects staying permanently in the mild ID area. Thyroid nodules at ultrasonography were found in 30% in both regions, but nodules were larger and more often palpable in the moderate ID area. Palpable goitre was found in 9.8% (mild ID) and 14.6% (moderate ID), P < 0.001. The greatest regional difference in thyroid abnormalities was found among men.CONCLUSION Marked differences in the prevalence of thyroid abnormalities were found in these regions with modest differences in iodine excretion.