OCULAR LIGHT DAMAGE

OCULAR LIGHT DAMAGE
复制标题

眼部光损伤

DOI:
--
复制
发表时间:
1993
影响因子:
3.3
通讯作者:
S. Zigman
S. Zigman
中科院分区:
生物学3区
文献类型:
--
作者:
S. Zigman

文献摘要

参考文献

被引文献

相似文献

本文综述了最近发表的关于环境短波辐射对眼组织的损伤和保护的论文。重点是295-450 nm范围内的辐射能,因为臭氧层会过滤掉短于295 nm的波长。从机理上讲,分别考虑UV-B(280- 315 nm)* 和UV-A(315400 nm)波长的影响是有用的,但自然环境总是包含295 - 400 nm的近紫外波长的混合物。一般来说,它是97%的UV-A和3%的UV-B。在中等纬度的太阳直射下,眼睛在30分钟内将接收到-300 kJ/m2的UV-A和10 kJ/m2的UV-B。近紫外线能量在眼睛的前段(角膜、透镜)被强烈吸收。例外的是在无晶状体眼中(z. e.在移除透镜后),后节也可以接收足够的近紫外线能量而被其损坏。由于透镜是有效的紫外线过滤器,对完整眼睛的视网膜的最大损害来自蓝光。蓝色视网膜光感受器吸收蓝光以维持视力,但它们也会因强烈暴露于蓝光而受到损害。蓝光和近紫外线辐射引起的细胞损伤通常会被所有活细胞和体液中存在的天然光敏剂(即)增强。核黄素)。天然抗氧化剂还可以保护眼组织免受光损伤。因此,近紫外线和蓝光能量可通过直接和光敏反应损伤眼组织。抗氧化剂可以用来防止这些毒性反应。
This review describes papers recently published on the damage to and protection of ocular tissues from environmental short-wavelength radiation. The focus is on radiant energy in the 295-450 nm range, as the ozone layer filters out wavelengths shorter than 295 nm. It is useful mechanistically to consider the effects of UV-B (280-3 15 nm)* and UV-A (3 15400 nm) wavelengths separately, but the natural environment always contains a mixture of near-UV wavelengths from 295 to 400 nm. Generally, it is 97% UV-A and 3% UV-B. From direct sun, at an intermediate latitude the eye would receive -300 kJ/m2 of UV-A and 10 kJ/m2 UV-B in 30 min. Near-UV energy is strongly absorbed in the anterior segment of the eye (cornea, lens). The exception is that in aphakic eyes (z.e. after lens removal), the posterior segment can also receive sufficient near-UV energy to be damaged by it. As the lens is an efficient UV filter, the greatest damage to the retina in intact eyes is from blue light. The blue retinal photoreceptors absorb blue light for vision, but they can also be damaged by intense exposure to it. Blue lightand near-UV radiation-induced cellular damage is often enhanced by natural photosensitizers present in all living cells and body fluids (i.e. riboflavin). Natural antioxidants also protect ocular tissues from light damage. Thus, near-UV and blue energy can damage the ocular tissues both by direct and photosensitized reactions. Antioxidants can be used to protect against these toxic reactions.
地塞米松可改善白化大鼠的视网膜光损伤。
DOI: 10.1016/0014-4835(92)90137-h
发表时间: 1992
影响因子: 3.4
作者:
Fu,J;Lam,TT;Tso,MO
通讯作者: Tso,MO
DOI: 10.3109/02713688908995756
发表时间: 1989
影响因子: 2
作者:
Rafferty,NS;Scholz,DL
通讯作者: Scholz,DL
反对黑色素作为短波长光视网膜光毒性介质的证据。
DOI: 10.1016/0014-4835(92)90069-5
发表时间: 1992
影响因子: 3.4
作者:
Rapp,LM;Smith,SC
通讯作者: Smith,SC
UVB照射对培养兔晶状体的生理影响。
DOI: --
发表时间: 1992
影响因子: 4.4
作者:
Hightower,K;McCready,J
通讯作者: McCready,J
筛选晶状体/视网膜中潜在的体内光毒性。
DOI: --
发表时间: 1990
期刊: Lens and eye toxicity research
影响因子: --
作者:
Roberts,JE;Dillon,J
通讯作者: Dillon,J