Properties of MHC class I presented peptides that enhance immunogenicity.
Properties of MHC class I presented peptides that enhance immunogenicity.
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MHC I类的性质提出了增强免疫原性的肽。
DOI：
10.1371/journal.pcbi.1003266
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发表时间：
2013-10
影响因子：
4.3
通讯作者：
Peters B
中科院分区：
文献类型：
--
作者：
Calis JJ;Maybeno M;Greenbaum JA;Weiskopf D;De Silva AD;Sette A;Keşmir C;Peters B
T细胞必须识别出在MHC分子上呈现的PETIDE，以激活其效应子功能，表明某些宠物比其他宠物更具免疫原性，因此更有可能是T细胞表位。这种免疫原性的差异可以从该分析中得出主要结论：首先，与先前的观察结果一致，我们表明，提出的肽的P4-6对免疫原性更为重要，其中一些氨基酸，尤其是那些具有较大和芳香的侧链的氨基酸与免疫原性相关。在http://tools.iedb.org/immunenogenity/）中，通过两个独立的表位发现研究对数据进行了验证。在过去成功地阐明了MHC-I表示途径中不同步骤的成功之后，影响免疫原性的变量将是研究T细胞表位和我们的重要下一步了解细胞免疫调查。
T-Cell必须识别出在MHC分子上激活的宠物，并引起其效应子的功能。识别T细胞似乎存在；大量的免疫原性和非免疫原性PMHC，分析这些集合的差异，某些氨基酸，尤其是那些具有较大和芳香的侧链的氨基酸，在接下来是T细胞与免疫原性相关的T细胞被合并为一个简单的模型，以预测新PMHC的免疫原性（该模型可在http://tools.iedb.org/immunogenogenity/上提供）。在过去的MHC-I呈现途径中成功阐明了不同步骤后，公认的病毒petides，影响免疫原性的变量将是研究T细胞的重要下一步表位和我们对细胞免疫复杂的理解。
T-cells have to recognize peptides presented on MHC molecules to be activated and elicit their effector functions. Several studies demonstrate that some peptides are more immunogenic than others and therefore more likely to be T-cell epitopes. We set out to determine which properties cause such differences in immunogenicity. To this end, we collected and analyzed a large set of data describing the immunogenicity of peptides presented on various MHC-I molecules. Two main conclusions could be drawn from this analysis: First, in line with previous observations, we showed that positions P4–6 of a presented peptide are more important for immunogenicity. Second, some amino acids, especially those with large and aromatic side chains, are associated with immunogenicity. This information was combined into a simple model that was used to demonstrate that immunogenicity is, to a certain extent, predictable. This model (made available at http://tools.iedb.org/immunogenicity/) was validated with data from two independent epitope discovery studies. Interestingly, with this model we could show that T-cells are equipped to better recognize viral than human (self) peptides. After the past successful elucidation of different steps in the MHC-I presentation pathway, the identification of variables that influence immunogenicity will be an important next step in the investigation of T-cell epitopes and our understanding of cellular immune responses. T-cells have to recognize peptides presented on MHC molecules to be activated and elicit their effector functions. Some peptide-MHC-I complexes (pMHCs) are better recognized by T-cells; we call such pMHCs more immunogenic. For other pMHCs, no recognizing T-cells seem to exist; we call such pMHCs non-immunogenic. We set out to determine which properties of pMHCs cause such differences in immunogenicity, by carefully collecting a large set of immunogenic and non-immunogenic pMHCs, and analysing the difference between these sets. Two important observations were made: First, in line with previous observations, we showed that positions P4–6 of a presented peptide are more important for immunogenicity. Second, some amino acids, especially those with large and aromatic side chains, seem to be better recognized by T-cells as they associate with immunogenicity. Next, this information was combined into a simple model to predict the immunogenicity of new pMHCs (this model is made available at http://tools.iedb.org/immunogenicity/). Interestingly, with this model we could show that T-cells are equipped to strongly recognize viral peptides. After the past successful elucidation of different steps in the MHC-I presentation pathway, the identification of variables that influence immunogenicity will be an important next step in the investigation of T-cell epitopes and our understanding of cellular immune responses.
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DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
影响因子：
4.8
作者：
Emmerich, NPN;Nussbaum, AK;Schild, H
通讯作者：
Schild, H
影响因子：
4.4
作者：
Hoof, Ilka;Perez, Carina L.;Karlsson, Annika C.
通讯作者：
Karlsson, Annika C.
免疫蛋白酶体塑造抗病毒CD8（+）T细胞在T细胞库水平和病毒抗原的表现下的免疫主导层次结构。
影响因子：
15.3
作者：
Chen, W;Norbury, C C;Cho, Y;Yewdell, J W;Bennink, J R
通讯作者：
Bennink, J R
影响因子：
30.5
作者：
通讯作者：
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