Improved free-breathing liver fat and iron quantification using a 2D chemical shift-encoded MRI with flip angle modulation and motion-corrected averaging.
Improved free-breathing liver fat and iron quantification using a 2D chemical shift-encoded MRI with flip angle modulation and motion-corrected averaging.
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DOI：
10.1007/s00330-022-08682-x
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发表时间：
2022-08
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
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3D化学位移编码（CSE）-MRI能够准确和精确地定量质子密度脂肪分数（PDFF）和R2*，肝脏脂肪和铁沉积的生物标志物。不幸的是，3D CSE-MRI需要可靠的屏气。具有顺序射频激励的自由呼吸2D CSE-MRI是一种运动稳健的替代方案，但具有低信噪比（SNR）的缺点。为了克服这一限制，这项工作探讨了翻转角调制（FAM）2D CSE成像与非局部均值（NLM）运动校正平均技术的组合。在这项前瞻性研究中，35名健康受试者（27名儿童/8名成人）在3 T MRI系统上成像。分别在屏气和自由呼吸期间采集多回波3D CSE（“3D”）和2D CSE FAM（“FAM”）图像，以获得肝脏的PDFF和R2* 图。多次重复FAM后处理直接平均（DA）和NLM为基础的平均和3D CSE相比，使用Bland-Altmann和回归分析。PDFF和R2* 图的图像质量由两名放射科医生使用Likert样量表（评分1-5，5=最佳）进行审查。与3D CSE相比，多次重复FAM-NLM显示出PDFF的极好一致性（回归斜率=1.0，R2=0.996）和R2* 的良好一致性（回归斜率1.08-1.15，R2≥0.899）。此外，多次重复FAM-NLM PDFF和R2* 图的伪影更少（PDFF评分3.8 vs. 3.2，p<0.0001; R2* 评分3.2 vs. 2.6，p<0.001），总体图像质量更好（PDFF评分4.0 vs. 3.5，p<0.0001; R2* 评分3.4 vs. 2.7，p<0.0001）。与传统屏气3D CSE-MRI相比，自由呼吸FAM-NLM提供了上级肝脏图像质量，同时最大限度地减少了PDFF和R2* 量化的偏倚。
3D chemical shift-encoded (CSE)-MRI enables accurate and precise quantification of proton density fat-fraction (PDFF) and R2*, biomarkers of hepatic fat and iron deposition. Unfortunately, 3D CSE-MRI requires reliable breath-holding. Free-breathing 2D CSE-MRI with sequential radiofrequency excitation is a motion-robust alternative but suffers from low signal-to-noise-ratio (SNR). To overcome this limitation, this work explores the combination of flip angle modulated (FAM) 2D CSE imaging with a non-local means (NLM) motion-corrected averaging technique. In this prospective study, 35 healthy subjects (27 children/8 adults) were imaged on a 3T MRI-system. Multi-echo 3D CSE (“3D”) and 2D CSE FAM (“FAM”) images were acquired during breath-hold and free-breathing, respectively, to obtain PDFF and R2* maps of the liver. Multi-repetition FAM was postprocessed with direct averaging (DA)- and NLM-based averaging and compared to 3D CSE using Bland-Altmann and regression analysis. Image quality of PDFF and R2* maps were reviewed by two radiologists using a Likert-like scale (score 1-5, 5=best). Compared to 3D CSE, multi-repetition FAM-NLM showed excellent agreement (regression slope=1.0, R2=0.996) for PDFF and good agreement (regression slope 1.08-1.15, R2≥0.899) for R2*. Further, multi-repetition FAM-NLM PDFF and R2* maps had fewer artifacts (score 3.8 vs. 3.2, p<0.0001 for PDFF; score 3.2 vs. 2.6, p<0.001 for R2*) and better overall image quality (score 4.0 vs. 3.5, p<0.0001 for PDFF; score 3.4 vs. 2.7, p<0.0001 for R2*). Free-breathing FAM-NLM provides superior image quality of the liver compared to the conventional breath-hold 3D CSE-MRI, while minimizing bias for PDFF and R2* quantification.
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影响因子：
3.3
作者：
Doneva, Mariya;Boernert, Peter;Lustig, Michael
通讯作者：
Lustig, Michael
影响因子：
3.3
作者：
Luo H;Zhu A;Wiens CN;Starekova J;Shimakawa A;Reeder SB;Johnson KM;Hernando D
通讯作者：
Hernando D
DOI：
10.1002/hep.26455
发表时间：
2013-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Noureddin M;Lam J;Peterson MR;Middleton M;Hamilton G;Le TA;Bettencourt R;Changchien C;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
3.3
作者：
Moriguchi, H;Lewin, JS;Duerk, JL
通讯作者：
Duerk, JL
DOI：
10.1002/hep.29797
发表时间：
2018-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Caussy C;Reeder SB;Sirlin CB;Loomba R
通讯作者：
Loomba R