ACTIVITIES OF LIPASE AND TRYPSIN IN DUODENAL JUICE OF INFANTS SMALL-FOR-GESTATIONAL-AGE
ACTIVITIES OF LIPASE AND TRYPSIN IN DUODENAL JUICE OF INFANTS SMALL-FOR-GESTATIONAL-AGE
复制标题
DOI：
10.1097/00005176-199104000-00006
复制
发表时间：
1991-04-01
影响因子：
2.9
通讯作者：
RAIHA, NCR
中科院分区：
文献类型：
--
作者：
BOEHM, G;BIERBACH, U;RAIHA, NCR
对 18 名小于胎龄、有不同程度宫内生长迟缓的低出生体重婴儿，测定餐前吸入的十二指肠液中胰脂肪酶和胰蛋白酶的活性以及胆汁酸的浓度。 将结果与 24 名适合胎龄、出生体重和产后年龄相当的低出生体重婴儿的结果进行了比较。 两种测量的胰酶活性与宫内生长迟缓程度呈负相关，宫内生长迟缓程度表示为个体出生体重与宫内生长曲线第10个百分位数的体重之间的差异（脂肪酶：r = -0.697，p < 0.001；胰蛋白酶：r = -0.739，p < 0.001）。 小于胎龄儿的胰蛋白酶活性在适合胎龄儿的胰蛋白酶活性范围内。 然而，出生体重> 400 g/kg 的生长迟缓婴儿的脂肪酶活性降低。 两组的胆汁酸浓度相似（分别为 4.60 +/- 2.51 和 4.55 +/- 2.26 mmol/L），足以激活人乳中胆汁盐刺激的脂肪酶。 数据表明，在宫内生长迟缓的婴儿中，十二指肠液中的脂肪酶活性可能是最佳脂肪消化的限制因素。 在此类婴儿的营养管理中应考虑这一点。
In 18 low birth weight infants, small for gestational age, with different degrees of intrauterine growth retardation the activities of pancreatic lipase and trypsin and the concentrations of bile acids were measured in preprandially aspirated duodenal juice. The results were compared to those of 24 low birth weight infants, appropriate for gestational age, with comparable birth weights and postnatal ages. The activities of both measured pancreatic enzymes were negatively correlated with the degree of intrauterine growth retardation, expressed as the difference between the individual birth weight and the weight of the 10th percentile of the intrauterine growth curve (lipase: r = -0.697, p < 0.001; trypsin: r = -0.739, p < 0.001). The activity of trypsin in the small for gestational age infants was within the range of that found in the infants appropriate for gestational age. However, the lipase activity was decreased in infants who presented with growth retardation of > 400 g/kg birth-weight. The concentrations of bile acids were similar in both groups (4.60 +/- 2.51 and 4.55 +/- 2.26 mmol/L, respectively) and sufficient for activating the bile salt stimulated lipase in human milk. The data suggest that in intrauterine growth retarded infants the lipase activity in the duodenal juice can be a limiting factor for optimal fat digestion. This should be considered in the nutritional management of such infants.