Modulation of the host immune response by cowpox virus.

Modulation of the host immune response by cowpox virus.
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DOI:
10.1016/j.micinf.2010.07.007
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发表时间:
2010-11
影响因子:
5.8
通讯作者:
Früh K
Früh K
中科院分区:
医学3区
文献类型:
--
作者:
Alzhanova D;Früh K

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牛痘病毒是欧亚大陆流行的一种人畜共患痘病毒,它感染大量宿主物种,使其无法根除。世界范围内天花疫苗接种计划的取消使得人类越来越容易受到正痘病毒的感染,从而导致越来越多的人畜共患感染,包括从家畜传播给人类的天花病毒。 CPXV 能够感染广泛的哺乳动物宿主的能力可能是由于以下事实:在正痘病毒中,CPXV 编码预期编码免疫调节蛋白的最完整的开放阅读框集。这使得 CPXV 对于研究痘病毒逃避和抵消宿主免疫反应的策略特别有意义。
Cowpox virus, a zoonotic poxvirus endemic to Eurasia, infects a large number of host species which makes its eradication impossible. The elimination of world-wide smallpox vaccination programs renders the human population increasingly susceptible to infection by orthopoxviruses resulting in a growing number of zoonotic infections including CPXV transmitted from domestic animals to humans. The ability of CPXV to infect a wide range of mammalian host is likely due to the fact that, among the orthopoxviruses, CPXV encodes the most complete set of open reading frames expected to encode immunomodulatory proteins. This renders CPXV particularly interesting for studying poxviral strategies to evade and counteract the host immune responses.
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