Family resemblance for glucose tolerance in a Melanesian population, the Tolai.
Family resemblance for glucose tolerance in a Melanesian population, the Tolai.
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美拉尼西亚托莱人的葡萄糖耐量具有家族相似性。
DOI：
10.1159/000153862
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发表时间：
1989
期刊：
影响因子：
1.8
通讯作者：
Zimmet,P
中科院分区：
文献类型：
--
作者：
King,H;Rao,DC;Bhatia,K;Koki,G;Collins,A;Zimmet,P
口服葡萄糖刺激后2小时血浆葡萄糖浓度的家族相似性通径分析未能检测到显著的遗传遗传性。没有代际差异，婚姻相似度适中。超过三分之一的兄弟姐妹环境相似是由非遗传因素造成的。文化遗传非常强，倾向于模仿基因遗传，文化可遗传性相当可观。为了与之前的研究具有可比性，肥胖指标被纳入了环境指数，这是一种对家庭环境的估计。由于肥胖在某种程度上似乎是一种可遗传的特征，在未来的研究中，对葡萄糖耐量和肥胖的家族相似性进行双变量研究可能会产生重要的额外见解。
Path analysis of family resemblance for plasma glucose concentration, 2 h after an oral glucose challenge, failed to detect significant genetic heritability. There were no intergenerational differences and marital resemblance was moderate. Over one-third of sibling environmental similarity was due to non-inherited factors. Cultural inheritance was very strong, tending to mimic genetic inheritance, and cultural heritability was considerable. Measures of obesity were included in the environmental index, an estimate of familial environment, in this analysis, for comparability with previous studies. Since obesity appears, in part, to be a heritable trait, in future studies a bivariate approach to family resemblance for both glucose tolerance and obesity could yield important additional insight.