Mismatch negativity in socially withdrawn children
Mismatch negativity in socially withdrawn children
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DOI：
10.1016/s0006-3223(03)00175-6
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发表时间：
2003-07-01
影响因子：
10.6
通讯作者：
Gordon-Salant, S
中科院分区：
文献类型：
--
作者：
Bar-Haim, Y;Marshall, PJ;Gordon-Salant, S
背景资料：听觉处理的个体差异与社交退缩、内向和其他形式的社交功能障碍有关。本研究的目的是调查的电生理反应，被认为是指数早期皮层听觉处理（不匹配负波，MMN）之间的社会撤回和更多的社交control children.Methods：听觉事件相关电位标准和偏差音刺激计算为23个社会撤回的儿童和22个对照组的特点。我们计算了额叶、中央和顶叶电极部位的MMN差异波形。结果：与社交能力较强的对照儿童相比，社交退缩儿童的MMN振幅较小，MMN潜伏期较长。结论：研究结果表明，儿童社交退缩早期皮质听觉处理中存在个体差异。减少MMN振幅和延迟的潜伏期可能是社会退缩的一个组成部分，在社会退缩的儿童和抑郁症和精神分裂症患者。在额叶皮层中存在次级MMN发生器，这可能提供了假设的额叶参与儿童社会退缩、精神分裂症和抑郁症与在这些条件下观察到的MMN减少之间的联系。生物精神病学2003;54：17-24（C）2003生物精神病学学会。
Background: Individual differences in auditory processing have been associated with social withdrawal, introversion, and other forms of dysfunction in social engagement. The goal of this study was to investigate the characteristics of an electrophysiologic response that is seen to index early cortical auditory processing (mismatch negativity, MMN) among socially withdrawn and more sociable control children.Methods: Auditory event-related potentials to standard and deviant tone stimuli were computed for 23 socially withdrawn children and 22 control subjects. We calculated MMN difference waveforms for frontal, central, and parietal electrode sites.Results: Socially withdrawn children had smaller MMN amplitude and longer MMN latencies compared with more sociable control children.Conclusions: The findings point to the involvement of individual differences in early cortical auditory processing in childhood social withdrawal. Reduced MMN amplitude and delayed latency may index a component of social withdrawal seen in socially withdrawn children and in depressed and schizophrenic patients. The existence of a secondary MMN generator in the frontal cortex may provide a link between the hypothesized frontal lobe involvement in childhood social withdrawal, schizophrenia, and depression and the MMN reductions seen in these conditions. Biol Psychiatry 2003;54:17-24 (C) 2003 Society of Biological Psychiatry.